2C-B的亚慢性毒性研究  

Study on subchronic toxicity of 2C-B

作　　者：张大雷[1] 杨波[2] 才志成[1] 洪玉 于维彪 廖林川[3] ZHANG Dalei;YANG Bo;CAI Zhicheng;HONG Yu;YU Weibiao;LIAO Linchuan(Forensic Science Section of Heilongjiang Public Security Department,Harbin 150008,China;School of Pharmacy,Harbin University of Commerce,Harbin 150076,China;West China School of Basic Medical Science and Forensic Medicine,Sichuan University,Chengdu 610041,China)

机构地区：[1]黑龙江省公安厅刑事技术总队,哈尔滨150008 [2]哈尔滨商业大学药学院,哈尔滨150076 [3]四川大学华西基础医学与法医学院,成都610041

出　　处：《哈尔滨商业大学学报（自然科学版）》2024年第3期266-272,280,共8页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：黑龙江省重点研发计划项目(GA21C021)。

摘　　要：研究4-溴-2,5-二甲氧基苯乙胺(4-bromo-2,5-dimethoxyphenethylamine,2C-B)的亚慢性毒性.通过对大鼠进行长期连续染毒,以体重变化、脏器系数、病理学检查及肝肾生化酶水平的影响探讨2C-B对机体造成损伤的情况.综合各指标结果分析长期服用2C-B会对心脏、肝脏、肺脏、肾脏、大脑产生损害,上述器官可能是2C-B毒性的靶器官.To study the subchronic toxicity of 4-bromo-2,5-dimethoxyphenethylamine(2C-B).The damage caused by 2C-B to the body was investigated by weight change,viscera coefficient,pathological examination and the effects on liver and kidney biochemical enzyme levels in rats through long-term continuous exposure.According to the results of various indexes,long-term administration of 2C-B will cause damage to the heart,liver,lung,kidney and brain,and these organs may be the target organs of 2C-B toxicity.

关 键 词：2C-B 亚慢性毒性 脏器系数 病理学检查 肝肾生化酶水平 

分 类 号：R917[医药卫生—药物分析学]