泌尿生殖系统支原体感染对系统性红斑狼疮患者疾病活动度及阴道微生态的影响  

Influence of urogenital system Mycoplasma infection on disease activity and vaginal microecology of patients with systemic lupus erythematosus

作　　者：袁媛[1] 王俊霞[1] 郭丽平[2] 任杰[1] 汪瑞霞[2] YUAN Yuan;WANG Jun-xia;GUO Li-ping;REN Jie;WANG Rui-xia(Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia O10050,China)

机构地区：[1]内蒙古医科大学附属医院妇产科,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院内科,内蒙古呼和浩特010050

出　　处：《中华医院感染学杂志》2024年第9期1353-1356,共4页Chinese Journal of Nosocomiology

基　　金：内蒙古自治区卫生健康科技计划项目(202101059)。

摘　　要：目的探讨泌尿生殖系统支原体感染对系统性红斑狼疮(SLE)患者疾病活动度及阴道微生态的影响。方法选取2020年6月-2023年6月内蒙古医科大学附属医院就诊的SLE合并泌尿生殖系统支原体感染患者62例为感染组,另选择60例未合并感染的SLE患者为未感染组,分析患者临床特征,比较两组患者阴道微生态、疾病活动度、免疫球蛋白、补体表达水平。结果与未感染组比较,感染组微生态失调患者占比升高(P<0.05);两组患者菌群密集度、pH值、过氧化氢酶、唾液酸苷酶、白细胞酯酶活性比较差异有统计学意义(P<0.05);感染组SLE疾病活动性指数(SLEDAI)评分为(21.51±2.42)分,未感染组SLEDAI评分为(15.42±2.57)分,两组SLEDAI评分比较差异有统计学意义(t=8.426,P<0.001);与未感染组比较,感染组患者抗核抗体(ANA)滴度、类风湿因子(RF)、血沉(ESR)、C-反应蛋白(CRP)及免疫球蛋白表达水平均升高(P<0.05),补体C3的表达水平降低(P<0.05)。结论支原体感染影响SLE患者疾病活动度,可能通过影响体液免疫激活水平介导患者的免疫损伤及疾病活动度。OBJECTIVE To explore the influence of urogenital system Mycoplasma infection on the disease activity and vaginal microecology of the patients with systemic lupus erythematosus(SLE).METHODS A total of 62 SLE patients complicated with urogenital system Mycoplasma infection who were treated in Affiliated Hospital of Inner Mongolia Medical University from Jun 2020 to Jun 2023 were assigned as the infection group,and 60 SLE patients who were not complicated with infection were chosen as the no infection group.The clinical characteristics of the patients were analyzed.The vaginal microecology,disease activity,immunoglobulin level and complement level were observed and compared between the two groups of patients.RESULTS The proportion of patients with microecological imbalance was significantly higher in the infection group than in the no infection group(P<0.05).There were significant differences in density of flora,pH value,catalase activity,sialidase activity and leukocyte esterase activity between the two groups of patients(P<0.05).The SLE disease activity index score was(21.51±2.42)points in the infection group,(15.42±2.57)points in the no infection group,and there was significant difference in the SLEDAI score between the two groups(t=8.426,P<0.001).The antinuclear antibodies(ANA)titers,rheumatoid factor(RF),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)level and immunoglobulin level were significantly higher in the infection group than in the no infection group(P<0.05),and the expression level of complement C3 of the infection group was significantly lower than that of the no infection group(P<0.05).CONCLUSION The Mycoplasma infection may affect the disease activity of the SLE patients and mediate the immune injury and disease activity by affecting the activation level of humoral immunity.

关 键 词：感染 生殖系统 支原体 系统性红斑狼疮 阴道微生态 体液免疫 

分 类 号：R593.241[医药卫生—内科学]