乙型肝炎孕妇miR-33a、miR-20a和miR-122表达及其新生儿感染状况  

Expressions of miR-33a,miR-20a and miR-122 in pregnant women with hepatitis B and incidence of neonatal infection

作　　者：方亮[1] 刘洁 陈颖 王菁 黄昱 FANG Liang;LIU Jie;CHEN Ying;WANG Jing;HUANG Yu(Huanggang Central Hospital,Huanggang,Hubei 438000,China)

机构地区：[1]黄冈市中心医院消化内科,湖北黄冈438000 [2]黄冈市中心医院妇产科,湖北黄冈438000

出　　处：《中华医院感染学杂志》2024年第9期1401-1404,共4页Chinese Journal of Nosocomiology

基　　金：湖北省科研基金资助项目(2021LK0351)。

摘　　要：目的分析乙型肝炎孕产妇微小核糖核酸(miR)-33a、miR-20a、miR-122表达水平及新生儿感染情况。方法选取2020年1月-2022年2月黄冈市中心医院收治的165例乙型肝炎孕妇设为感染组,另收集同期于医院产检的无乙型肝炎病毒(HBV)感染孕妇184名设为对照组;比较两组及不同病毒载量HBV孕妇miR-33a、miR-20a及miR-122表达情况,分析HBV不同病毒载量孕妇新生儿HBV感染情况。结果感染组miR-33a、miR-20a及miR-122水平高于对照组(P<0.05);感染组HBV-脱氧核糖核酸(DNA)阳性孕妇miR-33a、miR-20a及miR-122表达水平高于HBV-DNA阴性孕妇(P<0.05),感染组HBV-DNA阳性孕妇新生儿HBV感染率高于HBV-DNA阴性孕妇(P<0.05)。结论乙型肝炎孕妇miR-33a、miR-20a及miR-122表达增加,且随着HBV-DNA载量增加miR-33a、miR-20a及miR-122表达、新生儿HBV病毒感染率均升高。OBJECTIVE To investigate the expression levels of micro ribonucleic acid(miR)-33a,miR-20a and miR-122 in the pregnant women with hepatitis B and analyze the incidence of neonatal infection.METHODS Totally 165 pregnant women with hepatitis B who were treated in Huanggang Central Hospital from Jan 2020 to Feb 2022 were assigned as the infection group,meanwhile,184 pregnant women who received prenatal examination but did not have hepatitis B virus(HBV)infection were chosen as the control group.The expression levels of miR-33a,miR-20a and miR-122 were compared between the two groups and among the pregnant women with different viral loads of HBV,and the incidence of HBV infection in neonates was observed and compared among the pregnant women with different viral loads of HBV.RESULTS The expression levels of miR-33a,miR-20a and miR-122 of the infection group were significantly higher than those of the control group(P<0.05).In the infection group,the expression levels of miR-33a,miR-20a and miR-122 of the HBV-deoxyribonucleic acid(DNA)-positive pregnant women were significantly higher than those of the HBV-DNA-negative pregnant women(P<0.05);the incidence of HBV infection in neonates was significantly higher among the HBV-DNA-positive pregnant women than among the HBV-DNA-negative pregnant women(P<0.05).CONCLUSION The expression levels of miR-33a,miR-20a and miR-122 of the pregnant women with hepatitis B are elevated,the expression levels of miR-33a,miR-20a and miR-122 and the incidence of HBV infection in neonates show upward trends with the increase of HBV-DNA load.

关 键 词：乙型肝炎 孕妇 微小核糖核酸-20a 微小核糖核酸-33a 微小核糖核酸-122 相关性 

分 类 号：R512.62[医药卫生—内科学]