糖尿病视网膜病变合并HCMV感染与视网膜功能及胰岛素抵抗和糖脂代谢指标的关联  

Association of HCMV infection with retinal function,insulin resistance and glucolipid metabolism indexes of patients with diabetic retinopathy

作　　者：余凤娇 李萍 钱琴 张渊 曾平日 YU Feng-jiao;LI Ping;QIAN Qin;ZHANG Yuan;ZENG Ping-ri(Haikou Orthopaedic and Diabetes Hospital,Haikou,Hainan 570300,China)

机构地区：[1]海口市骨科与糖尿病医院护理部,海南海口570300 [2]海口市骨科与糖尿病医院医疗事业部感染办,海南海口570300

出　　处：《中华医院感染学杂志》2024年第10期1530-1533,共4页Chinese Journal of Nosocomiology

基　　金：海南省卫生健康行业科研项目(20A200384)。

摘　　要：目的探究糖尿病视网膜病变合并人巨细胞病毒(HCMV)感染对视网膜功能、胰岛素抵抗及糖脂代谢指标的影响。方法回顾性选取2020年5月-2023年5月海口市骨科与糖尿病医院收诊的103例糖尿病视网膜病变患者,根据是否合并HCMV感染分为感染组41例和非感染组62例,分析两组患者视网膜功能、胰岛素抵抗及糖脂代谢水平。结果103例糖尿病视网膜病变患者合并HCMV感染41例,HCMV感染的发生率为39.81%;感染组患者视网膜神经纤维层(RNFL)厚度、黄斑厚度、视野平均缺损(MD)值和空腹胰岛素(FINS)水平均低于非感染组(P<0.05),胰岛素抵抗指数(HOMA-IR)、空腹血糖(FBG)和糖化血红蛋白(HbA1c)水平高于非感染组(P<0.05)。结论糖尿病视网膜病变患者HCMV感染发生率高,HCMV感染可导致糖尿病视网膜病变患者脂糖代谢紊乱,加重视网膜病变程度,促进胰岛素抵抗。OBJECTIVE To explore the influence of human cytomegalovirus(HCMV)infection on retinal function,insulin resistance and glucolipid metabolism indexes of the patients with diabetic retinopathy.METHODS A total of 103 patients with diabetic retinopathy who were treated in Haikou Orthopaedic and Diabetes Hospital from May 2020 to May 2023 were retrospectively recruited as the research subjects and were divided into the infection group with 41 cases and the non-infection group with 62 cases according to the status of complication with HCMV infection.The retinal function,insulin resistance and glucolipid metabolism indexes were observed and compared between the two groups of patients.RESULTS Of the 103 patients with diabetic retinopathy,41 were complicated with HCMV infection,with the incidence rate of HCMV infection 39.81%.The thickness of retinal nerve fiber layer(RNFL),macular thickness,mean defect(MD)value and fasting insulin(FINS)level were significantly lower in the infection group than in the non-infection group(P<0.05);the homeostatic model assessment of insulin resistance(HOMA-IR),fasting blood glucose(FBG)level and glycosylated hemoglobin(HbA1c)level were significantly higher in the infection group than in the non-infection group(P<0.05).CONCLUSION The incidence of HCMV infection is high among the patients with diabetic retinopathy.The HCMV infection may result in the disturbance of glucolipid metabolism,aggravate the severity of retinopathy,and promote the insulin resistance.

关 键 词：糖尿病视网膜病变 人巨细胞病毒 视网膜功能 胰岛素抵抗 糖脂代谢 

分 类 号：R587.2[医药卫生—内分泌]