柴胡三石解毒汤加味对慢性肝炎的治疗效果及对患者COX-2、CD127表达的影响  

The effect of modified chaihusanshi Jiedu Decoction on chronic hepatitis and the expression of COX-2and CD127

作　　者：倪友琼 胡乃毅 张紫涵 NI Youqiong;HU Naiyi;ZHANG Zihan(Department of Gastroenterology,Wuhan Integrated Traditional Chinese and Western Medicine Hospital(Wuhan First Hospital),Wuhan Hubei 430030,China)

机构地区：[1]武汉市中西医结合医院(武汉市第一医院)消化内科,湖北武汉430030

出　　处：《四川中医》2024年第4期114-117,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:研究柴胡三石解毒汤加味对慢性肝炎的治疗效果及对患者环氧化酶-2(cyclooxygenase-2,COX-2)、CD127表达的影响。方法:本文选取2019年1月~2020年1月在我院就诊的慢性乙型肝炎患者86例,分为对照组(n=43)给予苦参素胶囊,中医组(n=43)给予柴胡三石解毒汤加味进行治疗。测定两组患者COX-2、CD127表达,评估症候评分,检测HBV-DNA值、AST、ALT、TBIL水平,统计治疗有效率。结果:两组治疗后COX-2表达、症候评分、HBV-DNA值,ALT、AST、TBIL水平低于两组治疗前,CD4^(+)CD127^(+)、CD8^(+)CD127^(+)表达高于两组治疗后(P<0.05)。中医组治疗后COX-2表达、症候评分、HBV-DNA值,ALT、AST、TBIL水平低于对照组治疗后,CD4^(+)CD127^(+)、CD8^(+)CD127^(+)表达高于对照组治疗后;治疗有效率高于对照组(P<0.05)。结论:慢性乙型肝炎采用柴胡三石解毒汤加味治疗后COX-2水平下降,CD127水平上升,临床症状、肝功能改善,HBV-DNA值降低,值得在临床推广应用。Objective:To study the effect of chaihusanshi Jiedu Decoction on chronic hepatitis and the expression of cyclooxygenase-2(COX-2)and CD127.Methods:In this study,86patients with chronic hepatitis B treated in our hospital from January 2019to January 2020were selected and divided into the control group(n=43)and the traditional Chinese medicine group(n=43),respectively,and the traditional Chinese medicine group(n=43)were given the added flavor of bupleurum Sanshi Jiedu decoction for treatment.The expression of COX-2and CD127in the two groups was measured,the symptom score was evaluated,HBV-DNA value,AST,ALT and TBIL levels were detected,and the therapeutic effectiveness was statistically analyzed.Results:After treatment,COX-2expression,symptom score,HBV-DNA value,ALT,AST and TBIL levels in both groups were lower than before treatment,and CD4^(+)CD127^(+)and CD8^(+)CD127^(+)expressions were higher than after treatment(P<0.05).After treatment,COX-2expression,symptom score,HBV-DNA value,ALT,AST and TBIL levels in the TCM group were lower than those in the control group,while CD4^(+)CD127^(+)and CD8^(+)CD127^(+)expressions were higher than those in the control group.The effective rate of treatment was higher than that of control group(P<0.05).Conclusion:After the treatment of chronic hepatitis B with buplehu Sanshi Jiedu decoction,COX-2level decreased,CD127level increased,clinical symptoms and liver function improved,HBV-DNA value decreased,which is worthy of clinical application.

关 键 词：柴胡三石解毒汤 加味 慢性乙型肝炎 环氧化酶-2 

分 类 号：R512.62[医药卫生—内科学]