健脾益气泻浊汤治疗COPD急性加重期的疗效及对中医证候积分、动脉血气以及肺功能的影响  

Curative effect of Jianpi Yiqi Xiezhuo Decoction on acute exacerbation of COPD and its influences on scores of TCM syndromes,arterial blood gas and pulmonary function

作　　者：侍文俊 孙广娟 王轶群[3] SHI Wenjun;SUN Guangjuan;WANG Yiqun(People's Liberation Army Support Unit 902hospital,Bengbu Anhui 230010,China;Thoracic Surgery Department,92nd Hospital of PLA Joint Logistic Support Force,Bengbu Anhui 230010,China;Department of Respiratory Medicine,92nd Hospital,PLA Joint Logistic Support Force,Bengbu,Anhui 230010,China)

机构地区：[1]中国人民解放军联勤保障部队九〇二医院中医内科,安徽蚌埠230010 [2]中国人民解放军联勤保障部队九〇二医院胸外科,安徽蚌埠230010 [3]中国人民解放军联勤保障部队九〇二医院呼吸内科,安徽蚌埠230010

出　　处：《四川中医》2024年第4期135-138,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探究健脾益气泻浊汤治疗慢性阻塞性肺疾病(COPD)急性加重期的疗效以及对中医证候积分、动脉血气以及肺功能的影响。方法:选取2020年1月~2022年12月期间,本院收治的COPD患者共计80例,采用随机数表法将上述研究对象划分为观察组(n=40)以及对照组(n=40);对照组患者接受COPD常规方案的治疗,观察组患者在上述治疗方案的基础之上联合使用健脾益气泻浊汤进行治疗;记录两组研究对象接受干预前后中医证候积分(咳嗽咳痰、气促气喘、怠倦乏力)、二氧化碳分压(PaCO_(2))、血氧分压(PaO_(2))、血氧饱和度(SaO_(2))水平、最大呼气第一秒呼出气体容积(FEV1)、最大呼气第一秒呼出气体容积/体积分数(FEV1/FVC)以及6min步行试验距离(6MWT)水平以及两组患者接受治疗后并发症发生率,并进行比较。结果:两组研究对象接受接受相应治疗后,主要临床症状的中医证候积分相比治疗前均出现下降,且观察组低于对照组(P<0.05);两组接受干预后,PaCO_(2)水平相比治疗前出现显著下降,与此同时,PaO_(2)、SaO_(2)水平相比治疗前出现明显提升(P<0.05);研究结果显示,两组研究对象接受治疗后,FEV1、FEV1/FVC以及6MWT水平相比治疗前均出现上升,且观察组高于对照组(P<0.05);另外,两组研究对象接受相应干预后,并发症发生率差异无统计学意义(P>0.05)。结论:健脾益气泻浊汤联合常规治疗方案应用于COPD急性加重期患者能够有效减轻患者临床症状、改善血气指标以及肺功能,且安全性高。Objective To explore the curative effect of Jianpi Yiqi Xiezhuo Decoction on acute exacerbation of chronic obstructive pulmonary disease(COPD)and its influences on scores of TCM syndromes,arterial blood gas and pulmonary function.Methods A total of 80patients with COPD admitted to the hospital were enrolled between January 2020and December 2022.According to random number table method,they were divided into observation group(n=40)and control group(n=40).The control group was given routine treatment regimen,while observation group was additionally treated with Jianpi Yiqi Xiezhuo Decoction.The scores of TCM syndromes(cough and expectoration,shortness of breath and asthma,fatigue),partial pressure of carbon dioxide(PaCO_(2)),partial pressure of blood oxygen(PaO_(2)),blood oxygen saturation(SaO_(2)),forced expiratory volume in 1second(FEV1),FEV1/forced vital capacity(FEV1/FVC)and 6-minute walking distance(6MWT)before and after interven-tion,and incidence of complications after treatment in the two groups were recorded and compared.Results After treatment,scores of TCM syndromes in both groups were decreased,which were lower in observation group than control group(P<0.05).After intervention,PaCO_(2) was significantly decreased,while PaO_(2) and SaO_(2) were significantly increased in both groups(P<0.05).The study results showed that after treatment,levels of FEV1,FEV1/FVC and 6MWT in both groups were increased,which were higher in observation group than control group(P<0.05).After intervention,there was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Jianpi Yiqi Xiezhuo Decoction combined with routine treatment regimen can effectively relieve clinical symptoms,improve blood gas indexes and pulmonary function in patients with acute exacerbation of COPD,with high safety.

关 键 词：健脾益气泻浊汤 慢性阻塞性肺疾病 急性加重期 中医证候积分 动脉血气 肺功能 

分 类 号：R563[医药卫生—呼吸系统]