运脾止泻汤结合玉屏散治疗对迁延性腹泻患儿免疫功能及胃肠道微生态的影响  

Effects of YunpiZhixie Decoction combined with Yuping SAN treatment on immune function and gastrointestinal microecology of children with prolonged diarrhea

作　　者：赖宇涛 郑辉乾 王晓萍 林茂增 LAI Yutao;ZHENG Huiqian;WANG Xiaoping(Department of Pediatrics,The 909th Hospital/Dongnan Hospital of Xiamen University,Zhangzhou Fujian 363005,China)

机构地区：[1]第九〇九医院/厦门大学附属东南医院儿科,福建漳州363005

出　　处：《四川中医》2024年第4期150-153,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:分析运脾止泻汤结合玉屏散治疗对迁延性腹泻患儿免疫功能及胃肠道微生态的影响。方法:选取2020年7月~2022年8月本院收治的迁延性腹泻患儿113例的临床资料,按照治疗方案不同分为对照组55例(西医治疗+运脾止泻汤)和观察组58例(西医治疗+运脾止泻汤+玉屏散)。对比两组总有效率、中医症状积分、免疫功能、胃肠道微生态、不良反应及复发率。结果:治疗后,观察组总有效率高于对照组,中医症状积分低于对照组(P<0.05)。治疗后,观察组CD4^(+)、CD4^(+)/CD8^(+)、IgA及IgG水平上升幅度大于对照组(P<0.05)。治疗后,观察组大肠杆菌、肠球菌数量少于对照组,双歧杆菌、乳酸杆菌及类杆菌数量多于对照组(P<0.05)。两组均未见呕吐、恶心、脱水等不良反应。随访6个月,观察组复发率低于对照组(P<0.05)。结论:运脾止泻汤结合玉屏散可提高迁延性腹泻患儿治疗总有效率,可减轻临床症状,具有改善免疫功能及调节胃肠道微生态的作用。Objective To analyze the effects of Yunpi Zhixie Decoction combined with Yuping SAN treatment on immune function and gastrointestinal microecology of children with prolonged diarrhea.Methods The clinical data of 113children with persistent diarrhea treated in our hospital from July 2020to August 2022were selected,and they were divided into control group of 55cases(Western medicine treatment+Yunpi Xueliang decoction)and observation group of 58cases(Western medicine treatment+Yunpi Xueliang decoction+Yuping SAN)according to different treatment regiments.The total curative effect rate,TCM syndrome score,immune function,gastrointestinal microecology,adverse reaction and recurrence rate were compared between the two groups.Results After treatment,the total curative effect rate of the observation group was higher than that of the control group,and the TCM syndrome score of the observation group was lower than that of the control group(P<0.05).After treat-ment,the increase of CD4^(+),CD4^(+)/CD8^(+),IgA and IgG levels in observation group was bigger than that in control group(P<0.05).After treatment,the number of Escherichia coli and enterococcus in observation group was lower than that in control group,while the number of bifidobacterium,lactobacillus and bacterioid bacteria in observation group was higher than that in control group(P<0.05).No adverse reactions such as vomiting,nausea and dehydration were observed in the two groups.After 6months of follow-up,the recurrence rate of observation group was lower than that of control group(χ^(2)=7.918,P<0.05).Conclusion Yunpi Zhixie Decoction combined with Yuping SAN can improve the total curative effect rate of children with prolonged diarrhea,reduce clinical symptoms,improve immune function and regulate gastrointestinal microecology.

关 键 词：运脾止泻汤 玉屏散 迁延性腹泻 免疫功能 胃肠道微生态 

分 类 号：R725.7[医药卫生—儿科]