健脾补肾强督法对早中期强直性脊柱炎的疗效评价  

Effect evaluation of invigorating spleen and tonifying kidney on early and middle ankylosing spondylitis

作　　者：陈婷 徐琳 杨代洪 CHEN Ting;XU Lin;YANG Daihong(Chongqing Dazu District People's Hospital,Dazu Chongqing 402360,China)

机构地区：[1]重庆市大足区人民医院,重庆大足402360

出　　处：《四川中医》2024年第4期175-178,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：重庆市科卫联合医学科研项目(编号:2019QNXM016)。

摘　　要：目的:探讨回顾性分析健脾补肾强督法对早中期强直性脊柱炎的疗效评价。方法:集取2020年3月~2021年4月在我院进行治疗的强直性脊柱炎87例患者,经双盲抽样法可将其分成观察组、对照组。对照组使用西药治疗,观察组则通过健脾补肾强督法进行治疗。对比两组的中医证候评分,酶联免疫吸附法测定内皮素-1(endothelin 1ET-1)、巨噬细胞移动抑制因子(Inhibitory factor of macrophage mobility MIF)、白介素1β(Interleukin 1β IL-1β)、白介素17(interleukin 17IL-17)、前列腺素E2(Prostaglandin E2PGE2)、疼痛介质环氧化酶-2(Pain mediator cyclooxygenase 2COX-2)水平,比较两组的疗效及不良反应发生率。结果:治疗后两组的颈项脊背僵紧疼痛、腰骶臀胯僵痛、四末不温评分及ET-1、COX-2、PGE2均低于治疗前(P<0.05);两组治疗后的SPARCC分值降低(P<0.05);但SSS分值差异不明显,无统计学差异(P>0.05);治疗后两组的IL-17、MIF、IL-1β水平均低于治疗前(P<0.05);相较于对照组,观察组的治疗有效率较高(73.81%VS 93.33%)(P<0.05);与对照组相比,观察组的不良反应发生率较低(21.43%VS 4.44%)(P<0.05)。结论:对早中期强直性脊柱炎患者给予补肾强督法进行治疗,可有助于缓解机体中的炎症反应,疗效较佳,安全性更高。Objective:To evaluate the effect of invigorating spleen and tonifying kidney on early and middle ankylosing spondylitis.Methods:87patients with ankylosing spondylitis treated in our hospital from March 2020to April 2021were divided into observation group and control group by double-blind sampling method.The control group was treated with Western medicine,while the observation group was treated with the method of strengthening the spleen,tonifying the kidney,and strengthening the Du meridian.Comparing the TCM syndrome scores of the two groups,Enzyme-linked immunosorbent assay determination of endothelin-1(ET-1),macrophage mobility inhibitory factor(MIF),interleukin 1β(IL-1β),interleukin 17(IL-17),prostaglandin E2(PGE2),pain media pro-cyclooxygenase-2(COX-2)level,Comparing the efficacy and the incidence of adverse effects between the two groups.Results:After treatment,neck stiffness pain,lumbosacral hip stiffness,ET-1,COX-2and PGE2 were lower than before treatment(P<0.05);SPARCC score decreased after treatment(P<0.05);but SSS score difference was not obvious,no statistical difference(P>0.05);The levels of IL-17,MIF and IL-1βafter treatment were lower than those before treatment(P<0.05).Compared with the control group,the effective rate of the observation group was higher(73.81%VS 93.33%)(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(21.43%VS 4.44%)(P<0.05).Conclusion:Treat patients with early and middle term ankylosing spondylitis with tonifying kidney and strengthening supervision method,which can help to relieve the inflammatory reaction in the body,with better curative effect and higher safety.

关 键 词：健脾补肾强督法 强直性脊柱炎 疗效 回顾性分析 

分 类 号：R593.23[医药卫生—内科学]