紫云英苷抗肿瘤作用相关信号通路的研究进展  

Research progress of signal pathways related to the anti-tumor effect of Astragalin

作　　者：肖鼎(综述) 白俊丞(综述) 张彬(审校)[1] XIAO Ding;BAI Juncheng;ZHANG Bin(Clinical Medical College,Inner Mongolia MinZu University,Tongliao 028000,China;Affiliated Hospital of Inner Mongolia MinZu University Cardiovascular surgery)

机构地区：[1]内蒙古民族大学临床医学院,通辽028000 [2]内蒙古民族大学附属医院心脏、血管外科

出　　处：《实用肿瘤学杂志》2024年第1期62-66,共5页Practical Oncology Journal

基　　金：内蒙古自治区直属高校项目(编号:GXKY22098)。

摘　　要：紫云英苷是一种天然的类黄酮,以抗肿瘤等多样化的药理应用而闻名。研究发现紫云英苷具有巨大的抗肿瘤潜力,通过调节PI3K/Akt信号通路、MAPKs信号通路、JAK/STAT信号通路、NF-κB信号通路、Notch1通路、microRNA的表达、肿瘤侵袭和转移等诱导肿瘤细胞凋亡,抑制肿瘤的增殖、侵袭和迁移。本文综述了近年来紫云英苷有关抗肿瘤信号通路的文献报道,分析并总结了每一条通路诱导肿瘤细胞凋亡的可能机制,以期为紫云英苷在抗肿瘤信号通路的开发和利用提供实验和理论依据。Astragalin is a natural flavonoid,which is known for its diverse pharmacological applications such as anti-tumor.The many studies have found that Astragalin has great anti-tumor potential by regulating PI3K/Akt signal pathway,MAPKs signal pathway,JAK/STAT signal pathway,NF-κB signal pathway,Notch1 pathway,microRNA expression,tumor invasion and metastasis.This article reviews the literature reports on anti-tumor signal pathway of Astragalin in recent years,analyzes and summarizes the possible mechanisms by which each pathway induces tumor cell apoptosis,in order to provide experimental and theoretical basis for the development and utilization of Astragalin in anti-tumor signal pathways.

关 键 词：紫云英苷 抗肿瘤 信号通路 

分 类 号：R285[医药卫生—中药学]