Bioprinting of inorganic-biomaterial/neural-stem-cell constructs for multiple tissue regeneration and functional recovery  

作　　者：Hongjian Zhang Chen Qin Zhe Shi Jianmin Xue Jianxin Hao Jinzhou Huang Lin Du Hongxu Lu Chengtie Wu 

机构地区：[1]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China [2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《National Science Review》2024年第4期222-238,共17页国家科学评论（英文版）

基　　金：This work was supported by the National Key Research and Development Program of China(2023YFB3813000);the National Natural Science Foundation of China(32225028 and 32130062);the Chinese Academy of Sciences Project for Young Scientists in Basic Research(YSBR073);the Shanghai Pilot Program for Basic Research-Chinese Academy of Sciences,Shanghai Branch(JCYJ-SHFY-2022-003);the project supported by the Space Application System of the China Manned Space Program.

摘　　要：Tissue regeneration is a complicated process that relies on the coordinated effort of the nervous,vascular and immune systems.While the nervous system plays a crucial role in tissue regeneration,current tissue engineering approaches mainly focus on restoring the function of injury-related cells,neglecting the guidance provided by nerves.This has led to unsatisfactory therapeutic outcomes.Herein,we propose a new generation of engineered neural constructs from the perspective of neural induction,which offers a versatile platform for promoting multiple tissue regeneration.Specifically,neural constructs consist of inorganic biomaterials and neural stem cells(NSCs),where the inorganic biomaterials endows NSCs with enhanced biological activities including proliferation and neural differentiation.Through animal experiments,we show the effectiveness of neural constructs in repairing central nervous system injuries with function recovery.More importantly,neural constructs also stimulate osteogenesis,angiogenesis and neuromuscular junction formation,thus promoting the regeneration of bone and skeletal muscle,exhibiting its versatile therapeutic performance.These findings suggest that the inorganic-biomaterial/NSC-based neural platform represents a promising avenue for inducing the regeneration and function recovery of varying tissues and organs.

关 键 词：3D bioprinting neural stem cells inorganic biomaterials neural constructs multiple tissue regeneration 

分 类 号：R318.08[医药卫生—生物医学工程]