Long-term outcomes of titanium-nitride-oxide coated stents and drug-eluting stents in acute coronary syndrome:A systematic review and meta-analysis  

作　　者：Muhammad Ahmed Ali Fahim Afia Salman Hira Anas Khan Syed Muhammad Hasan Muskan FatimaBhojani Sarah Aslam Amna Zia Ul Haq Vishal Reddy Bejugam Beena Muntaha Nasir Wajiha Gul Abdul Moeed Abdelrahman S Abdalla Muhammad Majid Muhammad Sohaib Asghar Md Al Hasibuzzaman 

机构地区：[1]Department of Internal Medicine,Dow University of Health Sciences,Karachi 74200,Pakistan [2]Department of Internal Medicine,North Central Bronx Hospital,Bronx,NY 10467,United States [3]Department of Urology,Center for Academic Medicine,Stanford University School of Medicine,Palo Alto,CA 33872,United States [4]Department of Cardiovascular Imaging,Cleveland Clinic,Cleveland,OH 44195,United States [5]Division of Nephrology and Hypertension,Mayo Clinic Rochester,Rochester,MN 55905,United States [6]Institute of Nutrition and Food Science,University of Dhaka,Dhaka 1000,Bangladesh

出　　处：《World Journal of Cardiology》2024年第5期293-305,共13页世界心脏病学杂志（英文版）（电子版）

摘　　要：BACKGROUND In severe cases of coronary artery disease,percutaneous coronary intervention provide promising results.The stent used could be a drug-eluting stent(DES)or a titanium-nitride-oxide coated stent(TiNOS).AIM To compare the 5-year effectiveness and safety of the two stent types.METHODS The following systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines,and PubMed/MEDLINE,Scopus,and Cochrane Central were searched from inception till August 2023.Primary outcomes were major adverse cardiac events(MACE),cardiac death,myocardial infarction(MI),cardiac death or MI,and ischemia-driven total lesion revascularization(ID-TLR).RESULTS Four randomized controlled trials(RCT),which analyzed a sum total of 3045 patients with acute coronary syndrome(ACS)after a median follow-up time of 5 years were included.Though statistically insignificant,an increase in the ID-TLR was observed in patients receiving TiNOSs vs DESs.In addition,MI,cardiac death and MI,and definite stent thrombosis(DST)were significantly decreased in the TiNOS arm.Baseline analysis revealed no significant results with meta-regression presenting non-ST elevated MI(NSTEMI)as a statistically significant covariate in the outcome of MACE.CONCLUSION TiNOS was found to be superior to DES in terms of MI,cardiac death or MI,and DST outcomes,however,the effect of the two stent types on ID-TLR and MACE was not significant.A greater number of studies are required to establish an accurate comparison of patient outcomes in TiNOS and DES.

关 键 词：STENTS DRUG-ELUTING Major adverse cardiac events All-cause death META-ANALYSIS 

分 类 号：R654.2[医药卫生—外科学]