Clinical efficacy of intradermal type Ⅰ collagen injections in treating skin photoaging in patients from high-altitude areas  

作　　者：Bin Yang Ao He Bin-Bin Bu Gong Zhuo Qing-Zhu Zhou Jia-Hang He Liu Liu Wen-Li Huang Xian Zhao 

机构地区：[1]Department of Plastic and Cosmetic Surgery,The Affiliated Calmette Hospital of Kunming Medical University,The First People's Hospital of Kunming,Calmette Hospital Kunming,Kunming 650224,Yunnan Province,China [2]Department of Dermatology,The People's Hospital of Chuxiong Yi Autonomous Prefecture,Chuxiong Yi Autonomous Prefecture 675099,Yunnan Province,China

出　　处：《World Journal of Clinical Cases》2024年第16期2713-2721,共9页世界临床病例杂志

摘　　要：BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injections stimulate collagen production,potentially improving skin quality.This study aims to assess the efficacy and safety of this treatment for photoaging.AIM To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating photoaging.METHODS This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan Province.Total six treatment sessions were conducted every 4 wk±3 d.Before and after each treatment,facial skin characteristics were quantified using a VISIA skin detector.Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector.The Face-Q scale was used for subjective evaluation of the treatment effect by the patients.RESULTS The skin thickness of the right cheek consistently increased after each treatment session compared with baseline.The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline.The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions.The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(P<0.05).These findings were also supported by skin ultrasound images.The feature count for the red areas and wrinkle feature count decreased following the treatment(P<0.05).VISIA assessments also revealed a decrease in the red areas after treatment.The Face-QSatisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session.The overall appearance of the patients impro

关 键 词：PHOTOAGING TypeΙcollagen Face-Q High-altitude area Skin photodamage Patient satisfaction 

分 类 号：R751[医药卫生—皮肤病学与性病学]