Impact of uterine artery embolization on ovarian function and pregnancy outcome after uterine-fibroids treatment:A prospective study  

作　　者：Jing-Lei Liu Zhi-Hui Liang Bao Cui Jian-Yu Liu Li Sun 

机构地区：[1]Department of Interventional Treatment,980(Bethune International Peace)Hospital of PLA Joint Logistics Support Forces,Shijiazhuang 050082,Hebei Province,China [2]Department of Obstetrics and Gynecology,980(Bethune International Peace)Hospital of PLA Joint Logistics Support Forces,Shijiazhuang 050082,Hebei Province,China

出　　处：《World Journal of Clinical Cases》2024年第15期2551-2559,共9页世界临床病例杂志

基　　金：Supported by Key Project of Medical Science Research in Hebei Province,China,No.20160005.

摘　　要：Uterine fibroids are benign tumors that originate from smooth muscle cells of the uterus.It is the most common gynecological disorder,affecting up to 80%of women of reproductive age.Uterine fibroids can cause various symptoms such as abnormal uterine bleeding,pelvic pain,infertility,and pregnancy complications.The treatment options for uterine fibroids include medical therapy,surgical intervention,and minimally invasive techniques.AIM To compare ovarian function of women with uterine fibroids who did or did not undergo uterine artery embolization(UAE).METHODS This prospective cohort study enrolled 87 women with symptomatic uterine fibroids who underwent UAE,and 87 women with the same symptoms who did not undergo UAE but received conservative management or other treatments.The two groups were matched for age,body mass index,parity,and baseline characteristics of uterine fibroids.The primary outcome was ovarian function that was evaluated by serum levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),and anti-Müllerian hormone(AMH),as well as ovarian reserve tests,such as antral follicle count(AFC)and ovarian volume(OV).The secondary outcome was fertility that was evaluated based on the menstrual cycle,ovulation,conception,pregnancy,and delivery.The participants were followed-up for 36 months and assessed at 1,3,6,12,24,and 36 months after treatment.RESULTS The study found that the most common minor complication of UAE was postembolization syndrome in 73.6% of women,resolving within a week.No significant differences were observed between the UAE group and the control group in serum levels of reproductive hormones(FSH,LH,E2,AMH)and ovarian reserve indicators(AFC,OV)at any point up to 36 months post-treatment.Additionally,there were no significant differences in conception,pregnancy,or delivery rates,with the average time to conception and gestational age at delivery being similar between the two groups.Birth weights were also comparable.Finally,there was no significant correlation betwee

关 键 词：Uterine fibroids Uterine artery embolization Ovarian function FERTILITY Pregnancy outcome Embolic agent 

分 类 号：R699[医药卫生—泌尿科学]