Vascular endothelium,a promising target for effectively treating fulminant diquat intoxication?  

作　　者：Xiang-Ying Cen Yi Chen Yong-An Xu Guang-Yao Zhong 

机构地区：[1]Department of Intensive Care Medicine,Key Laboratory for Prevention and Treatment of Critical Illness in Dongguan City,Binhaiwan Central Hospital of Dongguan,Dongguan 523903,Guangdong Province,China [2]Department of Emergency Medicine,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,Zhejiang Province,China [3]Department of Critical Care Medicine,Dongguan Eastern Central Hospital,Dongguan 523576,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2024年第17期2917-2920,共4页世界临床病例杂志

基　　金：Supported by High-Level Scientific Research Incubation Fund Project of Binhaiwan Central Hospital of Dongguan,No.2024003;Major Project of National-Zhejiang Provincial Administration of Traditional Chinese Medicine,No.GZY-ZJ-KJ-24030.

摘　　要：Following the withdrawal of paraquat,diquat(DQ)has emerged as the predominant herbicide.When people come into contact with or ingest DQ,may lead to poisoning and potentially fatal outcomes.Reports suggest that the mortality of DQ poisoning can be as high as 50%.DQ poisoning can be categorized as mild,moderate to severe or fulminant.In cases of fulminant poisoning,victims often succumb to multiple organ failure within 48 h.This presents a significant challenge in the clinical management.Scholars have discovered that oxidative stress,inflammatory injury,and cell apoptosis play crucial roles in the DQ poisoning.However,the underlying connection of the extensive organ damage remains unknown.The abnormal function and activity of endothelial cells(EC)should play a crucial role in tissue damage caused by DQ due to rich microcirculation and high sensitivity to perfusion in the vulnerable organs.However,reports on DQ-induced EC injury is rare.We made a preliminary discovery-the presence of severe vascular endothelial damage in the kidneys and lungs affected by DQ.Therefore,we hypothesize that DQ poisoning may be attributed to EC damage,ultimately resulting in multiple organ failure.

关 键 词：Diquat poisoning Endothelial cells Multiple organ dysfunction syndrome Treatment Oxidative stress 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]