Cardiovascular risk factors among older persons with cognitive frailty in middle income country  

作　　者：Azianah Mohamad Ibrahim Devinder Kaur Ajit Singh Arimi Fitri Mat Ludin Noor Ibrahim Mohamed Sakian Nurul Fatin Malek Rivan Suzana Shahar 

机构地区：[1]Centre for Healthy Ageing and Wellness,Faculty of Health Sciences,Universiti Kebangsaan Malaysia,Wilayah Persekutuan Kuala Lumpur 50300,Malaysia [2]Basic Medical Sciences,University of Cyberjaya,Selangor Darul Ehsan,Malaysia 63000,Malaysia

出　　处：《World Journal of Clinical Cases》2024年第17期3076-3085,共10页世界临床病例杂志

基　　金：Supported by Long-term Research Grant Scheme provided by Ministry of Education Malaysia,No.LRGS/1/2019/UM-UKM/1/4;Grand Challenge Grant Project 1 and Project 2,No.DCP-2017-002/1,No.DCP-2017-002/2.

摘　　要：BACKGROUND Cognitive frailty,characterized by the coexistence of cognitive impairment and physical frailty,represents a multifaceted challenge in the aging population.The role of cardiovascular risk factors in this complex interplay is not yet fully understood.AIM To investigate the relationships between cardiovascular risk factors and older persons with cognitive frailty by pooling data from two cohorts of studies in Malaysia.METHODS A comprehensive approach was employed,with a total of 512 communitydwelling older persons aged 60 years and above,involving two cohorts of older persons from previous studies.Datasets related to cardiovascular risks,namely sociodemographic factors,and cardiovascular risk factors,including hypertension,diabetes,hypercholesterolemia,anthropometric characteristics and biochemical profiles,were pooled for analysis.Cognitive frailty was defined based on the Clinical Dementia Rating scale and Fried frailty score.Cardiovascular risk was determined using Framingham risk score.Statistical analyses were conducted using SPSS version 21.RESULTS Of the study participants,46.3%exhibited cognitive frailty.Cardiovascular risk factors including hypertension(OR:1.60;95%CI:1.12-2.30),low fat-free mass(OR:0.96;95%CI:0.94-0.98),high percentage body fat(OR:1.04;95%CI:1.02-1.06),high waist circumference(OR:1.02;95%CI:1.01-1.04),high fasting blood glucose(OR:1.64;95%CI:1.11-2.43),high Framingham risk score(OR:1.65;95%CI:1.17-2.31),together with sociodemographic factors,i.e.,being single(OR 3.38;95%CI:2.26-5.05)and low household income(OR 2.18;95%CI:1.44-3.30)were found to be associated with cognitive frailty.CONCLUSION Cardiovascular-risk specific risk factors and sociodemographic factors were associated with risk of cognitive frailty,a prodromal stage of dementia.Early identification and management of cardiovascular risk factors,particularly among specific group of the population might mitigate the risk of cognitive frailty,hence preventing dementia.

关 键 词：Cognitive frailty Older persons Cardiovascular risk factors FRAILTY Mild cognitive impairment 

分 类 号：R473.73[医药卫生—护理学]