Therapeutic efficacy of methylprednisolone sodium succinate via diverse administration routes for mid-to high-frequency sudden sensorineural hearing loss  

作　　者：Xiang-Da Meng Ting-Ting Li Li-Min Deng 

机构地区：[1]Department of Otolaryngology,The First Affiliated Hospital of Qiqihar Medical University,Qiqihar 161041,Heilongjiang Province,China [2]Department of Otolaryngology Head and Neck Surgery,Harbin Medical University Affiliated Fourth Hospital University,Harbin 150001,Heilongjiang Province,China [3]Department of Facial Ward,The First Affiliated Hospital of Qiqihar Medical University,Qiqihar 161041,Heilongjiang Province,China

出　　处：《World Journal of Clinical Cases》2024年第18期3321-3331,共11页世界临床病例杂志

摘　　要：BACKGROUND Sudden sensorineural hearing loss(SSNHL),characterized by a rapid and unexplained loss of hearing,particularly at moderate to high frequencies,presents a significant clinical challenge.The therapeutic use of methylprednisolone sodium succinate(MPSS)via different administration routes,in combination with conventional medications,remains a topic of interest.AIM To compare the therapeutic efficacy of MPSS administered via different routes in combination with conventional drugs for the treatment of mid-to high-frequency SSNHL.METHODS The medical records of 109 patients with mid-to high-frequency SSNHL were analyzed.The patients were divided into three groups based on the route of administration:Group A[intratympanic(IT)injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection],Group B(intravenous injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection),and Group C(single IT injection of MPSS).The intervention effects were compared and analyzed.RESULTS The posttreatment auditory thresholds in Group A(21.23±3.34)were significantly lower than those in Groups B(28.52±3.36)and C(30.23±4.21;P<0.05).Group A also exhibited a significantly greater speech recognition rate(92.23±5.34)than Groups B and C.The disappearance time of tinnitus,time to hearing recovery,and disappearance time of vertigo in Group A were significantly shorter than those in Groups B and C(P<0.05).The total effective rate in Group A(97.56%)was significantly greater than that in Groups B and C(77.14%and 78.79%,χ^(2)=7.898,P=0.019).Moreover,the incidence of adverse reactions in Groups A and C was significantly lower than that in Group B(4.88%,3.03%vs 2.57%,χ^(2)=11.443,P=0.003),and the recurrence rate in Group A was significantly lower than that in Groups B and C(2.44%vs 20.00%vs 21.21%,χ^(2)=7.120,P=0.028).CONCLUSION IT injection of MPSS combined with conventional treatment demonstrates superior efficacy and safety compared to systemic administration via intravenous infusion and a sin

关 键 词：Sudden loss of hearing at middle-and high-frequency of the descending type Methylprednisolone sodium succinate Intratympanic injection Intravenous injection 

分 类 号：R714.2[医药卫生—妇产科学]