Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains  

作　　者：Zeng-Mei Sun Yuan-Ze Du Su-Yuan Wang Shu-Yao Sun Yan Ye Xue-Ping Sun Ming-Xia Li Hua He Wun-Chun Long Cheng-Hui Zhang Xuan-Yu Yao Wu-Yi Fan Ling Wang Yun-Hong Wu 

机构地区：[1]Department of Endocrinology and Metabolism,Hospital of the People's Government of the Tibet Autonomous Region in Chengdu,Chengdu 614000,Sichuan Province,China [2]Department of Nursing,Hospital of Chengdu Office of the People's Government of Tibet Autonomous Region,Chengdu 610041,Sichuan Province,China [3]Department of Endocrinology,Hospital of Chengdu Office of the People's Government of Tibet Autonomous Region,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Diabetes》2024年第6期1254-1262,共9页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by Health and Family Planning Project of Sichuan Province,No.17PJ069;Tibet Autonomous Region Science and Technology Program,No.XZ202303ZY0011G.

摘　　要：BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood glucose.Due to its increased usage in clinics,the number of studies investigating its accuracy has increased.However,its accuracy has not been investigated in highland populations in China.AIM To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to plains.METHODS Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 d.Throughout the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three meals.Moreover,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to<5 min.The accuracy of the FGM system was evaluated according to the CGM guidelines.Subsequently,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression method.RESULTS Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and B.According to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when the largest amplitude of glycemic excursion(L

关 键 词：Type 2 diabetes Flash glucose monitoring ACCURACY Continuous glucose monitor High altitude 

分 类 号：R587.1[医药卫生—内分泌]