Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes  

作　　者：Xiang-Yu Gao Chen-Xia Zhou Hong-Mei Li Min Cheng Da Chen Zi-Yi Li Bo Feng Jun Song 

机构地区：[1]Department of Endocrinology,East Hospital,Tongji University School of Medicine,Shanghai 200120,China [2]Department of Endocrinology,Qilu Hospital(Qingdao),Cheeloo College of Medicine,Shandong University,Qingdao 266000,Shandong Province,China [3]Department of Immunization Program,Huangdao District Center for Disease Prevention and Control,Qingdao 266400,Shandong Province,China

出　　处：《World Journal of Diabetes》2024年第6期1263-1271,共9页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by the Academic Leaders Training Program of Pudong Health Bureau of Shanghai,No.PWRd2023-03;Clinical Research Fund of Shanghai Municipal Commission of Health,No.202040136;National Natural Science Foundation of China,No.82070842;Jiangxi Health Commission Science and Technology Plan Project,No.202212838 and No.202212852.

摘　　要：BACKGROUND Cognitive dysfunction is the main manifestation of central neuropathy.Although cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking DM to cognitive dysfunction.Hyperglycemia is closely related to neurological abnormalities,while often disregarded in clinical practice.Changes in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM(T2DM).AIM To evaluate the concentrations of cerebral neurotransmitters in T2DM patients exhibiting different hemoglobin A1c(HbA1c)levels.METHODS A total of 130 T2DM patients were enrolled at the Department of Endocrinology of Shanghai East Hospital.The participants were divided into four groups according to their HbA1c levels using the interquartile method,namely Q1(<7.875%),Q2(7.875%-9.050%),Q3(9.050%-11.200%)and Q4(≥11.200%).Clinical data were collected and measured,including age,height,weight,neck/waist/hip circumferences,blood pressure,comorbidities,duration of DM,and biochemical indicators.Meanwhile,neurotransmitters in the left hippocampus and left brainstem area were detected by proton magnetic resonance spectroscopy.RESULTS The HbA1c level was significantly associated with urinary microalbumin(mALB),triglyceride,low-density lipoprotein cholesterol(LDL-C),homeostasis model assessment of insulin resistance(HOMA-IR),and beta cell function(HOMA-β),N-acetylaspartate/creatine(NAA/Cr),and NAA/choline(NAA/Cho).Spearman correlation analysis showed that mALB,LDL-C,HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c(P<0.05),whereas HOMA-βwas negatively correlated with the HbA1c level(P<0.05).Ordered multiple logistic regression analysis showed that NAA/Cho[Odds ratio(OR):1.608,95%confidence interval(95%CI):1.004-2.578,P<0.05],LDL-C(OR:1.627,95%CI:1.119-2.370,P<0.05),and HOMA-IR(OR:1.107,95%CI:1.031-1.188,P<0.01)were independent predictors of

关 键 词：Type 2 diabetes mellitus Hemoglobin A1c Proton magnetic resonance spectroscopy NEUROTRANSMITTERS Central neuropathy 

分 类 号：R587.1[医药卫生—内分泌]