Subclinical impairment of left ventricular myocardium function in type 2 diabetes mellitus patients with or without hypertension  

作　　者：Zeng-Guang Chen Guang-An Li Jun Huang Li Fan 

机构地区：[1]Department of Cardiology,The Affiliated Changzhou Second People’s Hospital with Nanjing Medical University,Changzhou 213000,Jiangsu Province,China [2]Department of Echocardiography,The Affiliated Changzhou Second People’s Hospital with Nanjing Medical University,Changzhou 213000,Jiangsu Province,China

出　　处：《World Journal of Diabetes》2024年第6期1272-1279,共8页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by the Science and Technology Project of Changzhou Health Commission,No.ZD202342.

摘　　要：BACKGROUND Cardiovascular disease has been the leading cause of morbidity and mortality for type 2 diabetes mellitus(T2DM)patients over the last decade.AIM To determine whether layer-specific global longitudinal strain(GLS)combined with peak strain dispersion(PSD)can be used to assess left ventricle(LV)myocardium systolic dysfunction in T2DM patients or without hypertension(HP).METHODS We enrolled 97 T2DM patients,70 T2DM+HP patients and 101 healthy subjects.Layer-specific GLS and PSD were calculated by EchoPAC software in apical three-,four-and two-chamber views.GLS of the epimyocardial,middle-layer and endomyocardial(GLSepi,GLSmid,and GLSendo)were measured and recorded.Receiver operating characteristic analysis was performed to detect LV myocardium systolic dysfunction in T2DM patients.RESULTS There were significant differences in GLSepi,GLSmid,GLSendo,and PSD between healthy subjects,T2DM patients and T2DM patients with HP(P<0.001).Trend tests yielded the ranking of healthy subjects>T2DM patients>T2DM with HP patients in the absolute values of GLSepi,GLSmid and GLSendo(P<0.001),while PSD was ranked healthy subjects<T2DM<T2DM with HP(P<0.001).Layer-specific GLS and PSD had high diagnostic efficiency for detecting LV myocardium systolic dysfunction in T2DM patients,however,the area under the curve(AUC)for layer-specific GLS and PSD combined was significantly higher than the AUCs for the individual indices(P<0.05).CONCLUSION Layer-specific GLS and PSD were associated with LV myocardium systolic dysfunction in T2DM patients,T2DM patients with HP.T2DM patients with HP have more severe LV myocardium systolic dysfunction than T2DM patients without HP and normal control patients.The combination of layer-specific GLS and PSD may provide additional prognostic information for T2DM patients with or without HP.

关 键 词：Type 2 diabetes mellitus HYPERTENSION Speckle tracking echocardiography Global longitudinal strain Peak strain dispersion 

分 类 号：R587.1[医药卫生—内分泌]