Reconsidering the role of depression and common psychiatric disorders as partners in the type 2 diabetes epidemic  

作　　者：Angelo Emilio Claro Clelia Palanza Marianna Mazza Alessandro Rizzi Andrea Corsello Linda Tartaglione Giuseppe Marano Giovanna Elsa Ute Muti Schuenemann Marta Rigoni Alfredo Pontecorvi Luigi Janiri Paola Muti Dario Pitocco 

机构地区：[1]Diabetes Care Unit,Department of Medical and Surgical Sciences,Fondazione Policlinico Universitario A Gemelli IRCCS,Rome 00168,Italy [2]Department of Biomedical,Surgical and Dental Sciences,University of Milan,Milan 20122,Italy [3]Istituto Italiano di Antropologia,ISItA,Rome 00100,Italy [4]Unit of Psychiatry,Department of Neurosciences,Fondazione Policlinico Universitario A Gemelli IRCCS,UniversitàCattolica del Sacro Cuore,Rome 00168,Italy [5]Dipartimento di Medicina e Chirurgia Traslazionale,UniversitàCattolica del Sacro Cuore,Rome 00168,Italy [6]Health Research Methods,Evidence and Impact Department,McMaster University,Ontario 1280,Canada [7]Department of Endocrine-Metabolic and Dermo-Rheumatology,Fondazione Policlinico Universitario A Gemelli IRCCS,UniversitàCattolica del Sacro Cuore,Rome 00168,Italy

出　　处：《World Journal of Diabetes》2024年第6期1374-1380,共7页世界糖尿病杂志（英文版）（电子版）

摘　　要：Common psychiatric disorders(CPDs)and depression contribute significantly to the global epidemic of type 2 diabetes(T2D).We postulated a possible pathophysiological mechanism that through Bridge-Symptoms present in depression and CPDs,promotes the establishment of emotional eating,activation of the reward system,onset of overweight and obesity and,ultimately the increased risk of developing T2D.The plausibility of the proposed pathophysiological mechanism is supported by the mechanism of action of drugs such as naltrexonebupropion currently approved for the treatment of both obesity/overweight with T2D and as separate active pharmaceutical ingredients in drug addiction,but also from initial evidence that is emerging regarding glucagon-like peptide 1 receptor agonists that appear to be effective in the treatment of drug addiction.We hope that our hypothesis may be useful in interpreting the higher prevalence of CPDs and depression in patients with T2D compared with the general population and may help refine the integrated psychiatric-diabetic therapy approach to improve the treatment and or remission of T2D.

关 键 词：DEPRESSION Glucagon-like peptide-1 receptor agonists Diabetes mellitus type 2 Stress psychological Sleep wake disorders Food addiction 

分 类 号：R587.1[医药卫生—内分泌] R749.1[医药卫生—内科学]