儿童脑型疟疾合并紫绀型先天性心脏病1例并文献复习  

A case report of cerebral malaria combined with cyanotic congenital heart disease in a child and literature review

作　　者：晋梅[1] 梁娟娟 石磊 贺逢孝 JIN Mei;LIANG Juanjuan;SHI Lei;HE Fengxiao(Department of Pharmacy,Gansu Maternal and Child Health Hospital(Gansu Provincial Central Hospital),Lanzhou,Gansu 730050,China;Department of Infectious Diseases,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou,Gansu 730000,China;Department of Geriatrics,Jiuquan People's Hospital,Jiuquan,Gansu 735000,China;Department of Cardiac Surgery,Lanzhou University Second Hospital,Lanzhou,Gansu 730000,China)

机构地区：[1]甘肃省妇幼保健院(甘肃省中心医院)药学部,甘肃兰州730050 [2]甘肃中医药大学附属医院感染性疾病科,甘肃兰州730000 [3]酒泉市人民医院老年医学科,甘肃酒泉735000 [4]兰州大学第二医院心脏外科,甘肃兰州730000

出　　处：《中国热带医学》2024年第5期624-626,共3页China Tropical Medicine

摘　　要：疟疾是非洲最致命的虫媒传染病之一,严重危害人类生命健康,其中脑型疟疾(cerebral malaria,CM)在儿童中有较高的发病率和死亡率,临床表现以神经系统症状为主,采用青蒿素衍生物为主的综合治疗。当脑型疟疾患儿合并先天性心脏病并诱发急性缺氧发作,在缺乏有效的检查和监护治疗手段时,诊疗面临极大困难,类似病例国内外鲜有报道。现笔者总结报告1例在援非期间救治的脑型疟疾合并紫绀型先天性心脏病患儿,经多学科协作抗疟、降颅压、营养神经及对症支持治疗后好转出院。结合目前的文献报道对该患儿在困难条件下的诊治过程进行讨论,以期为临床治疗提供参考。Malaria is one of the deadliest vector-borne infectious diseases in Africa,seriously endangering human life and health.Among them,cerebral malaria(CM)has a higher morbidity and mortality rate in children,with clinical manifestations primarily involving neurological symptoms,and comprehensive treatment mainly using artemisinin derivatives.When children with cerebral malaria are complicated by congenital heart disease and induce acute hypoxic attacks,the diagnosis and treatment face great difficulties in the absence of effective examination and monitoring treatments.Similar cases have rarely been reported at home and abroad.The paper summarizes and reports a case of a child with cerebral malaria combined with cyanotic congenital heart disease,treated during an aid mission to Africa,who was improved and discharged from the hospital after receiving multidisciplinary anti-malarial,intracranial pressure lowering,neurotrophic and symptomatic supportive treatment.This paper also discusses the diagnosis and treatment process of this child under difficult conditions,combined with current literature reports,in hopes of providing a reference for clinical treatment.

关 键 词：疟疾 先天性心脏病 青蒿琥酯 儿童 

分 类 号：R531[医药卫生—内科学]