基于TAT、PIC联合Padua评分在早期筛查慢性呼吸系统疾病合并VTE患者中的价值  

Value of TAT,PIC Combined with Padua Score in Early Screening of Patients with Chronic Respiratory Diseases Combined with VTE

作　　者：郑振羽 陈方榕[1] 刘岩 佘晖[1] Zheng Zhenyu(Department of Respiratory and Critical Care Medicine,The Second Hospital of Fuzhou,Fuzhou 350007)

机构地区：[1]福州市第二医院呼吸与危重症医学科,福建福州350007

出　　处：《黑龙江医药》2024年第3期510-513,共4页Heilongjiang Medicine journal

基　　金：福州市级科技计划项目(编号:2022-S-054)。

摘　　要：目的:探究基于凝血酶-抗凝血酶复合物(TAT)、纤溶酶-α2纤溶酶抑制剂复合物(PIC)联合Padua评分在早期筛查慢性呼吸系统疾病合并静脉血栓栓塞症(VTE)患者中的价值。方法:收集2022年10月—2023年9月时间段内在我院呼吸与危重症医学科接受住院诊疗的慢性呼吸系统疾病患者100例,按照是否发生VTE分组,分为VTE组(n=43)与非VTE组(n=57)。接受血清TAT、PIC检测分析以及Padua评分评估。比较两组血清TAT、PIC水平以及Padua评分。采用ROC曲线分析血清TAT、PIC与Padua评分单一或联合对慢性呼吸系统疾病合并VTE的诊断效能。结果:VTE组患者的血清TAT、PIC水平以及Padua评分均较非VTE组患者高(P<0.05),且VTE组患者VTE高风险(Padua评分≥4分)占比高于非VTE组(P<0.05)。经分析,当血清TAT≥16.18ng/mL时,其诊断灵敏度为71.43%、特异度为77.59%;当血清PIC≥3.10μg/mL时,其诊断灵敏度为76.60%、特异度为86.79%;当Padua评分≥4分时,其诊断灵敏度为80.85%、特异度为90.57%。经血清TAT、PIC与Padua评分联合诊断的AUC为0.959,其诊断灵敏度为93.48%、特异度为100.00%。结论:慢性呼吸系统疾病合并VTE患者血清TAT、PIC水平及Padua评分明显较高,通过TAT、PIC联合Padua评分可早期筛查慢性呼吸系统疾病合并VTE,且诊断效能较高。Objective:To explore the value of thrombine-antithrombin complex(TAT),plasminase-α2 plasminase inhibitor complex(PIC)combined with Padua score in early screening of patients with chronic respiratory diseases complicated with venous thromboembolism(VTE).Methods:100 patients with chronic respiratory diseases who received inpatient treatment in the Department of Respiratory and Critical Care Medicine of our hospital from October 2022 to September 2023 were collected and divided into VTE group(n=43)and non-VTE group(n=57)according to whether VTE occurred.TAT,PIC and Padua were evaluated.Serum TAT,PIC levels and Padua scores were compared between the two groups.ROC curve was used to analyze the diagnostic efficacy of serum TAT,PIC and Padua scores alone or combined in chronic respiratory diseases with VTE.Results:The serum TAT,PIC levels and Padua scores in VTE group were higher than those in non-VTE group(P<0.05),and the proportion of patients with high risk of VTE(Padua score≥4 points)in VTE group was higher than that in non-VTE group(P<0.05).When serum TAT≥16.18ng/mL,the diagnostic sensitivity was 71.43%and the specificity was77.59%.When serum PIC≥3.10μg/mL,the diagnostic sensitivity and specificity were 76.60%and 86.79%respectively.When Padua score was≥4,the diagnostic sensitivity was 80.85%and the specificity was 90.57%.The AUC of serum TAT,PIC and Padua was 0.959,the diagnostic sensitivity was 93.48%,and the specificity was 100.00%.Conclusion:The serum TAT and PIC levels and Padua score of patients with chronic respiratory diseases combined with VTE are significantly higher,and TAT and PIC combined with Padua score can be used for early screening of chronic respiratory diseases combined with VTE,and the diagnostic efficacy is higher.

关 键 词：凝血酶-抗凝血酶复合物 纤溶酶-α2纤溶酶抑制剂复合物 Padua评分 慢性呼吸系统疾病合并静脉血栓栓塞症 

分 类 号：R56[医药卫生—呼吸系统]