Deer antler stem cell niche: An interesting perspective  

作　　者：Claudia Cavallini Elena Olivi Riccardo Tassinari Chiara Zannini Gregorio Ragazzini Martina Marcuzzi Valentina Taglioli Carlo Ventura 

机构地区：[1]National Laboratory of Molecular Biology and Stem Cell Engineering,National Institute of Biostructures and Biosystems-Eldor Lab,Bologna 40128,Italy [2]Eldor Lab,Bologna 40128,Italy [3]Department of Medical and Surgical Sciences(DIMEC),University of Bologna,Bologna 40138,Italy

出　　处：《World Journal of Stem Cells》2024年第5期479-485,共7页世界干细胞杂志（英文版）（电子版）

摘　　要：In recent years,there has been considerable exploration into methods aimed at enhancing the regenerative capacity of transplanted and/or tissue-resident cells.Biomaterials,in particular,have garnered significant interest for their potential to serve as natural scaffolds for cells.In this editorial,we provide commentary on the study by Wang et al,in a recently published issue of World J Stem Cells,which investigates the use of a decellularized xenogeneic extracellular matrix(ECM)derived from antler stem cells for repairing osteochondral defects in rat knee joints.Our focus lies specifically on the crucial role of biological scaffolds as a strategy for augmenting stem cell potential and regenerative capabilities,thanks to the establishment of a favorable microenvironment(niche).Stem cell differen-tiation heavily depends on exposure to intrinsic properties of the ECM,including its chemical and protein composition,as well as the mechanical forces it can generate.Collectively,these physicochemical cues contribute to a bio-instructive signaling environment that offers tissue-specific guidance for achieving effective repair and regeneration.The interest in mechanobiology,often conceptualized as a form of“structural memory”,is steadily gaining more validation and momen-tum,especially in light of findings such as these.

关 键 词：Extracellular matrix Antler stem cells Stem cell niche Regenerative medicine Decellularized scaffolds Cell memory 

分 类 号：R318[医药卫生—生物医学工程]