Effects of combined aerobic,resistance and inspiratory training in patients with pulmonary hypertension:A systematic review  

作　　者：Christos Kourek Antonia Zachariou Eleftherios Karatzanos Michalis Antonopoulos Theodora Soulele Andreas Karabinis Serafim Nanas Stavros Dimopoulos 

机构地区：[1]Department of Clinical Ergospirometry,Exercise and Rehabilitation Laboratory,1^(st)Department of Critical Care Medicine,Evangelismos Hospital,National and Kapodistrian University of Athens,Athens 10676,Greece [2]Department of Cardiology,417 Army Share Fund Hospital of Athens,Athens 11521,Greece [3]Cardiac Surgery ICU,Onassis Cardiac Surgery center,Athens 17674,Attica,Greece [4]Cardiac Surgery ICU,Onassis Cardiac Surgery Center,Athens 17674,Greece [5]Cardiac Surgery Intensive Care Unit,Onassis Cardiac Surgery Center,Athens 17674,Greece [6]Department of Clinical Ergospirometry,Exercise and Rehabilitation Laboratory,National and Kapodistrian University of Athens,Athens 10676,Greece

出　　处：《World Journal of Critical Care Medicine》2024年第2期168-179,共12页世界重症医学杂志

摘　　要：BACKGROUND Pulmonary hypertension(PH)is a serious progressive disorder of the modern world,characterized by endothelial dysfunction and impaired vasoreactivity.Patients with PH usually present exercise intolerance from the very early stages and reduced exercise capacity.Exercise training has been shown to have beneficial effects in patients with cardiovascular comorbidities.However,data regarding the effects of combined exercise training programs in patients with PH still remains limited.AIM To investigate the effects of combined exercise training programs on exercise capacity and quality of life in patients with PH.METHODS Our search included all available randomized controlled trials(RCTs)regarding combined aerobic,resistance and inspiratory training programs in patients with PH in 4 databases(Pubmed,PEDro,Embase,CINAHL)from 2012 to 2022.Five RCTs were included in the final analysis.Functional capacity,assessed by peak VO_(2)or 6-min walking test(6MWT),as well as quality of life,assessed by the SF-36 questionnaire,were set as the primary outcomes in our study.RESULTS Peak VO_(2)was measured in 4 out of the 5 RCTs while 6MWT was measured in all RCTs.Both indices of functional capacity were significantly increased in patients with PH who underwent combined exercise training compared to the controls in all of the included RCTs(P<0.05).Quality of life was measured in 4 out of 5 RCTs.Although patients improved their quality of life in each group,however,only 2 RCTs demonstrated further improvement in patients performing combined training compared to controls.CONCLUSION By this systematic review,we have demonstrated that combined aerobic,resistance and inspiratory exercise training is safe and has beneficial effects on aerobic capacity and quality of life in patients with PH.Such exercise training regimen may be part of the therapeutic strategy of the syndrome.

关 键 词：Pulmonary hypertension Exercise training Peak VO2 Functional capacity Quality of life 

分 类 号：R563.8[医药卫生—呼吸系统]