Screening for metabolic dysfunction-associated fatty liver disease:Time to discard the emperor’s clothes of normal liver enzymes?  

作　　者：Chen-Xiao Huang Xiao-Dong Zhou Calvin Q Pan Ming-Hua Zheng 

机构地区：[1]Metabolic Dysfunction-Associated Fatty Liver Disease Research Center,Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang Province,China [2]Department of Cardiovascular Medicine,The Key Laboratory of Cardiovascular Diseases of Wenzhou,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang Province,China [3]Division of Gastroenterology and Hepatology,Department of Medicine,New York University Langone Health,New York University Grossman School of Medicine,New York,NY 11355,United States [4]Institute of Hepatology,Wenzhou Medical University,Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province,Wenzhou 325000,Zhejiang Province,China

出　　处：《World Journal of Gastroenterology》2024年第22期2839-2842,共4页世界胃肠病学杂志（英文版）

基　　金：the National Natural Science Foundation of China,No.82070588 and No.82370577.

摘　　要：Metabolic dysfunction-associated fatty liver disease(MAFLD)is the most prevalent chronic liver condition worldwide.Current liver enzyme-based screening methods have limitations that may missed diagnoses and treatment delays.Regarding Chen et al,the risk of developing MAFLD remains elevated even when alanine aminotransferase levels fall within the normal range.Therefore,there is an urgent need for advanced diagnostic techniques and updated algorithms to enhance the accuracy of MAFLD diagnosis and enable early intervention.This paper proposes two potential screening methods for identifying individuals who may be at risk of developing MAFLD:Lowering these thresholds and promoting the use of noninvasive liver fibrosis scores.

关 键 词：Metabolic dysfunction-associated fatty liver disease Non-alcoholic fatty liver disease Alanine aminotransferase Liver enzymes SCREENING Noninvasive liver fibrosis scores 

分 类 号：R563.1[医药卫生—呼吸系统] R575.5[医药卫生—内科学]