Whole-eye transplantation: Current challenges and future perspectives  

作　　者：Anna Scarabosio Pier Luigi Surico Vlad Tereshenko Rohan Bir Singh Carlo Salati Leopoldo Spadea Glenda Caputo Pier Camillo Parodi Caterina Gagliano Jonathan M Winograd Marco Zeppieri 

机构地区：[1]Department of Plastic Surgery,University Hospital of Udine,Udine 33100,Italy [2]Department of Plastic Surgery,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02114,United States [3]Schepens Eye Research Institute of Mass Eye and Ear,Harvard Medical School,Boston,MA 02114,United States [4]Department of Ophthalmology,University Hospital of Udine,Udine 33100,Italy [5]Eye Clinic,Policlinico Umberto I,"Sapienza"University of Rome,Rome 00142,Italy [6]Department of Medicine and Surgery,University of Enna"Kore",Enna 94100,Italy [7]Eye Clinic Catania University San Marco Hospital,Viale Carlo Azeglio Ciampi 95121 Catania,Italy

出　　处：《World Journal of Transplantation》2024年第2期28-39,共12页世界移植杂志

摘　　要：Whole-eye transplantation emerges as a frontier in ophthalmology,promising a transformative approach to irreversible blindness.Despite advancements,formidable challenges persist.Preservation of donor eye viability post-enucleation necessitates meticulous surgical techniques to optimize retinal integrity and ganglion cell survival.Overcoming the inhibitory milieu of the central nervous system for successful optic nerve regeneration remains elusive,prompting the exploration of neurotrophic support and immunomodulatory interventions.Immunological tolerance,paramount for graft acceptance,confronts the distinc-tive immunogenicity of ocular tissues,driving research into targeted immunosup-pression strategies.Ethical and legal considerations underscore the necessity for stringent standards and ethical frameworks.Interdisciplinary collaboration and ongoing research endeavors are imperative to navigate these complexities.Biomaterials,stem cell therapies,and precision immunomodulation represent promising avenues in this pursuit.Ultimately,the aim of this review is to critically assess the current landscape of whole-eye transplantation,elucidating the challenges and advancements while delineating future directions for research and clinical practice.Through concerted efforts,whole-eye transplantation stands to revolu-tionize ophthalmic care,offering hope for restored vision and enhanced quality of life for those afflicted with blindness.

关 键 词：Eye TRANSPLANTATION Optic nerve Nerve regeneration Immunological tolerance 

分 类 号：R617[医药卫生—外科学] R551.2[医药卫生—临床医学]