Frequency of and reasons behind non-listing in adult patients referred for liver transplantation: Results from a retrospective study  

作　　者：Marco Biolato Luca Miele Giuseppe Marrone Claudia Tarli Antonio Liguori Rosaria Calia Giovanni Addolorato Salvatore Agnes Antonio Gasbarrini Maurizio Pompili Antonio Grieco 

机构地区：[1]Department of Medical and Surgical Sciences,CEMAD,Fondazione Policlinico Universitario Agostino Gemelli IRCCS,Rome 00168,Italy [2]Department of Translational Medicine and Surgery,Catholic University of Sacred Heart,Rome 00168,Italy

出　　处：《World Journal of Transplantation》2024年第2期99-106,共8页世界移植杂志

摘　　要：BACKGROUND Few studies have evaluated the frequency of and the reasons behind the refusal of listing liver transplantation candidates.AIM To assess the ineligibility rate for liver transplantation and its motivations.METHODS A single-center retrospective study was conducted on adult patients which entailed a formal multidisciplinary assessment for liver transplantation eligibility.The predictors for listing were evaluated using multivariable logistic regression.RESULTS In our center,314 patients underwent multidisciplinary work-up before liver transplantation enlisting over a three-year period.The most frequent reasons for transplant evaluation were decompensated cirrhosis(51.6%)and hepatocellular carcinoma(35.7%).The non-listing rate was 53.8%and the transplant rate was 34.4%for the whole cohort.Two hundred and five motivations for ineligibility were collected.The most common contraindications were psychological(9.3%),cardiovascular(6.8%),and surgical(5.9%).Inappropriate or premature referral accounted for 76(37.1%)cases.On multivariable analysis,a referral from another hospital(OR:2.113;95%CI:1.259–3.548)served as an independent predictor of non-listing.CONCLUSION A non-listing decision occurred in half of our cohort and was based on an inappropriate or premature referral in one case out of three.The referral from another hospital was taken as a strong predictor of non-listing.

关 键 词：Controindication ELIGIBILITY Evaluation REFERRAL Personalized medicine 

分 类 号：R657.3[医药卫生—外科学]