明胶/二水磷酸氢钙/二水硫酸钙复合多孔支架材料的制备与性能研究  

Preparation and Properties of Gelatin/Brushite/Gypsum Composite Porous Scaffold Materials

作　　者：雷云 胡雯 李艳 LEI Yun;HU Wen;LI Yan(Faculty of Architecture Engineering,Kunming Metallurgy College,Kunming 650033,China)

机构地区：[1]昆明冶金高等专科学校建筑工程学院,云南昆明650033

出　　处：《昆明冶金高等专科学校学报》2024年第2期73-77,共5页Journal of Kunming Metallurgy College

摘　　要：以二水磷酸氢钙、α-半水硫酸钙为原料,利用搅拌干燥喷雾法制备二水磷酸氢钙/二水硫酸钙核壳结构复合球状颗粒,并将球状颗粒与明胶进行复合,之后在模具成型的方法,最终制备出明胶/二水磷酸氢钙/二水硫酸钙复合多孔生物支架。通过XRD、SEM等方法对制备出的复合多孔支架材料进行了检测,研究分析了支架材料的成分、形貌以及内部的结构特征,并就支架材料的体外降解性、孔隙率、力学性能和细胞毒性等进行了探究。结果表明:明胶/二水磷酸氢钙/二水硫酸钙复合多孔支架有一定的孔洞结构,平均初始孔隙率达到61%,可以满足骨组织工程对于支架材料的要求;并且支架材料具有良好的抗压强度,平均数值达到(6.1±0.05)MPa;该复合多孔支架的体外模拟体液浸泡降解周期约80 d,无细胞毒性,在骨组织修复方面具有良好的应用前景。Brushite/gypsum core-shell composite spherical particles were prepared by agitating spray drying method using brushite andα-calcium sulfate as raw materials,and then gelatin was mixed with the prepared spherical particles and collected by stacking in a mold.In the method,a gelatin/brushite/gypsum composite porous biological scaffold was finally prepared.The composition,morphology and structural characteristics of the prepared composite porous scaffolds were characterized by XRD and SEM.Its internal structure,composition and morphology were studied and analyzed,and its external degradability and mechanical properties were analyzed.The results show that the gelatin/brushite/gypsum composite porous scaffold has a certain pore structure,and the average porosity is 61%,which can meet the requirements of the bone tissue engineering for the scaffold material;the composite porous scaffold has good compressive strength and average resistance.The compressive strength is(6.1±0.05)MPa,the composite porous scaffold has no cytotoxicity,and the in vitro degradation in SBF solution cycle is about 80 days.This material has a broad prospect in bone tissue repair.

关 键 词：二水磷酸氢钙 骨组织 多孔支架 

分 类 号：TQ050.43[化学工程]