功能年龄在衰老个体化评价中的研究进展  

Research advances in functional age in individualized evaluation of aging

作　　者：何艳 牛越[2] 冯哲 张伟光[2] 陈香美[1,2] HE Yan;NIU Yue;FENG Zhe;ZHANG Weiguang;CHEN Xiangmei(Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;Department of Nephrology,the First Medical Center,Chinese PLA General Hospital,State Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing Key Laboratory of Kidney Diseases Research,Beijing 100853,China)

机构地区：[1]成都中医药大学,四川成都610075 [2]解放军总医院第一医学中心肾脏病医学部,肾脏疾病全国重点实验室,国家慢性肾病临床医学研究中心,肾脏疾病研究北京市重点实验室,北京100853

出　　处：《解放军医学院学报》2024年第4期418-423,共6页Academic Journal of Chinese PLA Medical School

基　　金：国家重点研发计划(2022YFC3602903)。

摘　　要：时序年龄(chronological age,CA)是以时间表示自出生以后经历期间的个体年龄,即个体的实际年龄。但CA在评价个体功能状态和衰老进程方面可能存在不足,因此需要更准确的衡量指标。功能年龄是反映个体器官或系统的真实年龄,相比CA更够更准确地评估个体真实功能状态以及衰老进程。然而由于研究功能年龄的学者出发点、关注点和学科不同,对于功能年龄的命名也不同。本综述主要总结不同器官系统的功能年龄以及构建过程中使用的标志物和方法,并将功能年龄分为系统/器官功能年龄和整体功能年龄,同时介绍在临床中的应用现状,为未来构建更准确的功能年龄提供参考。Chronological age(CA)is the actual age of an individual expressed in the time during the period of experience since birth.However,CA may be inadequate in evaluating individual functional status.Therefore,more accurate measurement indicators are needed.Functional age reflects the actual age of individual organs or systems and can assess individuals'actual functional state and aging process more accurately than CA.However,due to the different starting points,concerns and disciplines of functional age researchers,the names of functional age are also different.This review mainly summarizes the functional age of different organ systems and the markers and methods used in the construction process.It divides the functional age into system/organ functional age and overall functional age.At the same time,it introduces the current clinical application status and guides the construction of a more accurate functional age.

关 键 词：功能年龄 时序年龄 生物学年龄 衰老 衰老标志物 

分 类 号：R71[医药卫生—妇产科学]