锌剂通过NF-κB信号通路修复肠黏膜屏障损伤的研究进展  

Research advances in repair of intestinal mucosal barrier damage by zinc agents via NF-κB signaling pathway

作　　者：王永才 单庆文[1] WANG Yongcai;SHAN Qingwen(Department of Pediatrics,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西医科大学第一附属医院儿科,广西南宁530021

出　　处：《解放军医学院学报》2024年第4期430-434,共5页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(82060101)。

摘　　要：肠黏膜屏障是机体抵御肠腔内有害抗原的第一道防线,缺血缺氧、理化免疫、肠道菌群变化、氧自由基等多种因素的参与可导致肠黏膜屏障损伤。锌是一种至关重要的微量元素,可通过减少肠道损伤、抗炎和肠道微生物群重建机制来调节黏膜完整性。锌可通过调节NF-κB信号通路来减少肠道损伤、对抗炎症、重构肠道微生物群来调节黏膜完整性,以达到修复肠道黏膜损伤的目的。这为研究锌剂修复肠黏膜屏障损伤的机制提供了参考。The intestinal mucosal barrier is the body's first line of defense against harmful antigens in the intestinal lumen.Damage to the intestinal mucosal barrier can result from various factors such as ischemia,hypoxia,physical and chemical immunity,changes in intestinal flora,and oxygen-free radicals.Zinc is a crucial trace element that regulates mucosal integrity by reducing intestinal damage,exerting anti-inflammatory effects,and rebuilding the intestinal microbiota.By modulating the NF-κB signaling pathway,zinc can reduce intestinal damage,counter inflammation,and reconstruct the intestinal microbiota to regulate mucosal integrity,thereby repairing intestinal mucosal damage,which provides reference for the study of the mechanisms of zinc agents in repairing intestinal mucosal barrier damage.

关 键 词：肠黏膜屏障 肠上皮细胞 锌 紧密连接 NF-ΚB通路 

分 类 号：R245[医药卫生—针灸推拿学]