三结构域TRIM34蛋白的相关功能研究进展  

Research advances in related functions of tripartite-motif protein 34

作　　者：张鹏飞[1,2] 胡毅[2,3] ZHANG Pengfei;HU Yi(Graduate School,Chinese PLA General Hospital,Beijing 100853,China;Department of Oncology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of Medical Oncology,the Fifth Medical Center,Chinese PLA General Hospital,Beijing 100071,China)

机构地区：[1]解放军总医院研究生院,北京100853 [2]解放军总医院第一医学中心肿瘤内科,北京100853 [3]解放军总医院第五医学中心肿瘤医学部,北京100071

出　　处：《解放军医学院学报》2024年第4期440-444,共5页Academic Journal of Chinese PLA Medical School

摘　　要：三结构域蛋白(tripartite-motif proteins,TRIM)是由三段结构域组成并以其独特结构命名的基本蛋白,参与调节细胞信号传导、凋亡、免疫应答、炎症和肿瘤调控等多种生理病理过程。目前在人类中已知的TRIM蛋白有80多种,TRIM34蛋白是其蛋白家族的重要成员,既往对于TRIM34蛋白的研究相对局限。最近的研究表明,TRIM34在抗肿瘤治疗、预测肿瘤预后、抗HIV病毒和微生物感染、以及调控免疫应答等过程中发挥了重要作用。本文在简要总结TRIM34蛋白的分子结构和功能结构域特点的基础上,详细介绍了TRIM34蛋白的共性特征,聚焦荟萃了TRIM34蛋白的促进细胞凋亡、阻断炎症肿瘤通路、预测免疫治疗疗效、预防逆转录病毒感染和刺激多核细胞形成等功能,为全面认识该蛋白提供一定的理论参考。TRIM(tripartite-motif proteins)is a basic protein composed of three domains and named after its unique structure,which is involved in regulating many physiological and pathological processes such as cell signal transduction,apoptosis,immune response,inflammation and tumor regulation.At present,there are more than 80 known TRIM proteins in human beings,and TRIM34 protein is an important member of its protein family,but researches on TRIM34 protein are relatively limited in the past.Recent studies show that TRIM34 plays an important role in anti-tumor therapy,tumor prognosis prediction,anti-HIV and microbial infection,and immune response regulation.Based on a brief summary of the molecular structure and functional domain characteristics of TRIM34 protein,this paper introduces the common characteristics of TRIM34 protein in detail,focusing on the functions of TRIM34 protein,such as promoting cell apoptosis,blocking inflammatory tumor pathway,predicting the curative effect of immunotherapy,preventing retrovirus infection and stimulating the formation of multinucleated cells,which can provide some theoretical references for a comprehensive understanding of TRIM 34 protein.

关 键 词：三结构域蛋白 TRIM34 免疫 抗炎 抗肿瘤治疗 

分 类 号：R392[医药卫生—免疫学]