HPLC-三重四级杆质谱法测定医疗废水中抗生素残留  

Determination of Antibiotic Residues in Medical Wastewater by HPLC-Triple Quadrupole Mass Spectrometry

作　　者：张文斌 郑璇 张秀 赵晶 王俭 ZHANG Wenbin;ZHENG Xuan;ZHANG Xiu;ZHAO Jing;WANG Jian(Chongqing Ecological Environment Monitoring Center,Chongqing 401147,China)

机构地区：[1]重庆市生态环境监测中心,重庆401147

出　　处：《环境监测管理与技术》2024年第3期55-58,72,共5页The Administration and Technique of Environmental Monitoring

基　　金：重庆市地方标准制修订基金资助项目(cstc2021jxjl20021)。

摘　　要：采用固相萃取/高效液相色谱-三重四级杆质谱法同时测定医疗废水中的20种超痕量抗生素残留,通过优化试验条件,使方法在1.00μg/L~100μg/L范围内线性良好,方法检出限为0.24 ng/L~1.22 ng/L。空白水样和实际水样3个质量浓度水平的加标回收率分别为80.2%~108%和75.8%~114%,6次测定结果的RSD分别为2.4%~8.4%和1.7%~8.1%。将该方法用于测定重庆市2家三甲医院医疗废水中的超痕量抗生素残留,结果有11种抗生素检出,其余均为未检出。20 kinds of ultra-trace antibiotic residues in medical wastewater were determined by solid phase extraction-high performance liquid chromatography-triple quadrupole mass spectrometry.By optimizing the experimental conditions,the method had good linearity in the range of 1.00μg/L~100μg/L.The method detection limits were from 0.24 ng/L to 1.22 ng/L.The recoveries of spiked blank and actual samples with three mass concentration levels were 80.2%~108%and 75.8%~114%,respectively,and the RSDs of six measurements were 2.4%~8.4%and 1.7%~8.1%,respectively.This method was used to determine ultra-trace antibiotic residues in the medical wastewater from two Three-A hospitals in Chongqing,the results showed that 11 antibiotics were detected and the rest were not detected.

关 键 词：抗生素 固相萃取 高效液相色谱串联质谱法 医疗废水 

分 类 号：O657.63[理学—分析化学]