FGF19在新生儿高胆红素血症的表达及其与肠道菌群特点、β-GD活性的相关性  

Expression of FGF19 in neonatal hyperbilirubinemia and its correlation withintestinal flora characteristics and β-glucuronidase activity

作　　者：陈立佳 陈焕[1] 王莹 魏玉凤 叶立伟[1] 张军[1] CHEN Lijia;CHEN Huan;WANG Ying;WEI Yufeng;YE Liwei;ZHANG Jun(Department of Pediatrics,Daqing Longnan Hospital,Daqing,Heilongjiang 163000,China;Department of Neonatology,Changchun Municipal Children’s Hospital,Changchun,Jilin 130012,China)

机构地区：[1]大庆龙南医院儿科,黑龙江大庆163000 [2]长春市儿童医院新生儿科,长春130012

出　　处：《重庆医学》2024年第11期1666-1669,共4页Chongqing medicine

基　　金：黑龙江省卫生健康委员会科研计划项目(20220606031027)。

摘　　要：目的 探讨成纤维细胞生长因子(FGF)19在新生儿高胆红素血症的表达及其与肠道菌群特点、β-葡萄糖醛酸苷酶(β-GD)活性的相关性。方法 选取2022年1月至2023年1月大庆龙南医院75例高胆红素血症新生儿作为观察组,选取同期45例非高胆红素血症新生儿作为对照组。比较两组血清FGF19、总胆红素、总胆汁酸(TBA)水平及肠道菌群特点、β-GD活性,Pearson分析高胆红素血症新生儿FGF19、肠道菌群、β-GD活性与血清总胆红素、TBA水平相关性,FGF19与肠道菌群特点、β-GD活性相关性。结果 与对照组比较,观察组FGF19水平更低,总胆红素、TBA水平和β-GD活性更高,双歧杆菌、乳杆菌数量更少,大肠埃希菌数量更多,差异有统计学意义(P<0.05)。高胆红素血症新生儿FGF19水平及双歧杆菌、乳杆菌数量与血清总胆红素、TBA水平呈负相关,大肠埃希菌数量、β-GD活性与血清总胆红素、TBA水平呈正相关(P<0.05)。高胆红素血症新生儿FGF19水平与双歧杆菌、乳杆菌数量呈正相关,与大肠埃希菌数量、β-GD活性呈负相关(P<0.05)。结论 高胆红素血症新生儿血清FGF19异常低表达,且与肠道菌群紊乱及β-GD活性有关。Objective To investigate the expression of fibroblast growth factor(FGF)19 in neonatal hyperbilirubinemia and its correlation with intestinal flora characteristics andβ-glucuronidase(β-GD)activity.Methods Seventy-five neonates with hyperbilirubinemia in Daqing Longnan Hospital from January 2022 to January 2023 were selected as the observation group and 45 neonates with non-hyperbilirubinemia during the same period were selected as the control group.Serum FGF19,total bilirubin and total bile acid levels,intestinal flora characteristics andβ-GD activity were compared between the two groups.The correlation between FGF19,intestinal flora andβ-GD activity with serum total bilirubin level and total bile acid(TBA)level in newborns with hyperbilirubinemia and the correlation between FGF19 with the intestinal flora characteristics andβ-GD activity were analyzed by the Pearson method.Results The serum FGF19 level in the observation group was lower than that in the control group,the total bilirubin and TBA levels andβ-GD activity were higher,the number of bifidobacterium and Lactobacillus were much less,the number of Escherichia coli was more,and the differences were statistically significant(P<0.05).The FGF19 level and number of bifidobacterium and Lactobacillus in newborns with hyperbilirubinemia were negatively correlated with the levels of serum total bilirubin and TBA levels,while the number of Escherichia coli andβ-GD activity were positively correlated with the levels of serum total bilirubin and TBA(P<0.05).FGF19 in hyperbilirubinemia neonates was positively correlated with the number of bifidobacterium and Lactobacillus,and negatively correlated with Escherichia coli a ndβ-GD activity(P<0.05).Conclusion The serum FGF19 in neonates with hyperbilirubinemia is abnormally low expressed,moreover which is related to intestinal flora disturbance andβ-GD activity.

关 键 词：成纤维细胞生长因子19 新生儿 高胆红素血症 肠道菌群特点 Β-葡萄糖醛酸苷酶 

分 类 号：R722.1[医药卫生—儿科]