病证结合动物模型宏观表征指标评价方法研究进展  

Research Progress on Evaluation Methods of Macroscopical Indicators of Disease and Syndrome Combined with Animal Models

作　　者：崔钰伟 臧凝子[1,2] 李品[2] 庞立健[2] 吕晓东[1] CUI Yuwei;ZANG Ningzi;LI Pin;PANG Lijian;LYU Xiaodong(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中华中医药学刊》2024年第6期195-198,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82274440);国家自然科学基金青年科学基金项目(82004294);中国博士后科学基金项目(2022MD723797);辽宁省教育厅青年科技人才“育苗”项目(L202046);辽宁中医药大学“中医藏象理论及应用教育部重点实验室”开放基金项目(zyzx2210)。

摘　　要：动物实验在中医药的发展中起重要作用,病证结合动物实验更是实现中医药现代化的必经之路。近年来,随着病证结合动物实验的不断发展,动物模型的建立与评价体系均在不断完善,然而其模型的宏观指标评价仍有很大不足,多数实验仅通过观察法来判断动物的宏观体征,常具有主观性且缺乏科学性。因此,通过文献综述方法系统地整理了目前病证结合动物模型各证候宏观表征评价指标的进展,并提出各宏观指标定量评价模式,认为此模式为动物实验发展路上的可行且必要途径,同时结合实验室行为学设备等来探索证候定量的测量方法,以期通过专业的仪器设备来评价证候指标,进而解决动物实验模型指标评价的关键问题,完善宏观指标评价标准,推动病证结合动物实验进一步的发展。Animal experiments play an important role in the development of traditional Chinese medicine,and the combina-tion of disease and syndrome with animal experiments is the only way to realize the modernization of traditional Chinese medicine.In recent years,with the continuous development of animal experiments combining disease and syndrome,the establishment of ani-mal models and the evaluation system are constantly improving.However,the evaluation of macro indicators of their models is still very insufficient.Most experiments judge the macro signs of animals only by observation,which is often subjective and unscientif-ic.Therefore,through literature review,the author systematically sorted out the current progress of macro-representation evalua-tion indexes of syndromes combined with disease and syndrome in animal models and proposed a quantitative evaluation model of macro-indicators,which was considered to be a feasible and necessary approach for the development of animal experiments.At the same time,the author explored quantitative measurement methods of syndromes through combining the laboratory behavioral e-quipment in order to evaluate the syndrome indicators through professional instruments and equipment,and then solve the key problems of animal experimental model index evaluation,improve the evaluation criteria of macro indicators and promote the fur-ther development of combining disease and syndrome with animal experiments.

关 键 词：证候 病证结合 宏观指标 研究进展 定量模式 

分 类 号：R2-03[医药卫生—中医学]