补肾宣肺方对慢性支气管炎急性发作期患者IP-10、Rantes及炎症因子的影响  

Effects of Bushen Xuanfei Recipe(补肾宣肺方)on IP-10,Rantes and Inflammatory Factors in Patients with Acute Attack of Chronic Bronchitis

作　　者：徐伟俊 刘琪[1] 孙潇君 宋业琳 丁明罡 XU Weijun;LIU Qi;SUN Xiaojun;SONG Yelin;DING Minggang(Qingdao Traditional Chinese Medicine Hospital(Qingdao Hiser Hospital),Qingdao Hiser Hospital Affiliated of Qingdao University,Qingdao 266033,Shandong,China)

机构地区：[1]青岛市中医医院(市海慈医院),青岛大学附属青岛市海慈医院,山东青岛266033

出　　处：《中华中医药学刊》2024年第6期219-223,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(2017-332)。

摘　　要：目的 观察补肾宣肺方联合西药治疗慢性支气管炎急性发作对患者干扰素-γ诱导蛋白10(IP-10)、T细胞表达分泌的活化调节因子(Rantes)及炎症因子的影响。方法 选取青岛市中医医院(市海慈医院)青岛大学附属青岛市海慈医院于2021年6月—2022年12月收治的慢性支气管炎急性发作患者140例,采用随机数字表法,将合格受试者按1∶1原则分为两组。对照组70例采用西药治疗,观察组70例采用补肾宣肺方联合西药治疗,两组均治疗2周。统计两组2周后的总有效率和不良反应率,记录两组中医证候积分、生活质量评分及IP-10、Rantes、炎症因子、血气指标、第1秒用力呼气容积占预计值百分比(FEV1%)预计值的变化。结果 疗效方面:观察组总有效率高于对照组(P<0.05)。中医证候方面:治疗后,两组咳嗽、咳痰、胸满气短及痰黄黏稠积分较治疗前下降(P<0.05),观察组上述中医证候积分低于对照组(P<0.05)。检验方面:治疗后,两组干扰素-γ(IFN-γ)、白细胞介素-10(IL-10)较治疗前上升,IP-10、Rantes、高敏-C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)较治疗前下降(P<0.05),观察组IFN-γ、IL-10高于对照组,IP-10、Rantes、hs-CRP、IL-6低于对照组(P<0.05)。血气和肺功能方面:治疗后,两组动脉血氧分压(PaO_(2))、FEV1%预计值较治疗前上升(P<0.05),动脉血二氧化碳分压(PaCO_(2))较治疗前下降(P<0.05),观察组血气指标、FEV1%预计值优于对照组(P<0.05)。生活质量方面:治疗后,两组生理机能、社会功能、生理职能、躯体疼痛、精力、一般健康、情感职能及精神状况评分较治疗前上升(P<0.05),观察组生活质量评分高于对照组(P<0.05)。安全性方面:两组不良反应比较,无统计学意义(P>0.05)。结论 补肾宣肺方联合西药治疗慢性支气管炎急性发作可降低IP-10、Rantes及炎症因子的表达,改善血气指标和FEV1%预计值,提高生活质量和疗效。Objective To observe the effect of Bushen Xuanfei Recipe(补肾宣肺方)combined with Western medicine on in-terferon-γinducing protein 10(IP-10),T cell expression and secretion of activating regulatory factors(Rantes)and inflamma-tory factors in patients with acute exacerbation of chronic bronchitis.Methods A total of 140 patients with acute attack of chronic bronchitis treated in Sanya people's Hospital from August 2018 to April 2020 were randomly divided into two groups according to the ration of 1∶1.70 in the control group were treated with western medicine,and 70 cases in the observation group were treated with Bushen Xuanfei Recipe combined with western medicine.Both groups were treated for 2 weeks.The total effective rate and adverse reaction rate of the two groups after 2 weeks were counted,and the changes of TCM syndrome scores,quality of life score and IP-10,Rantes,inflammatory factors,blood gas index and forced expiratory volume in the first second as a percentage of the expected value(FEV1%)were recorded.Results Efficacy:The total effective rate in the observation group was higher than that in the control group(P<0.05).TCM syndromes:The scores of cough,expectoration,chest shortness of breath and yellow and sticky phlegm in the two groups were lower than those in the control group(P<0.05).Inspection:The levels of interferon-γ(IFN-γ)and interleukin-10(IL-10)in the two groups were higher than those before treatment,and the levels of IP-10,Rantes,high-sensitivity C reactive protein(hs-CRP)and interleukin-6(IL-6)were lower than those before treatment(P<0.05).The levels of IFN-γand IL-10 in the observation group were higher than those in the control group and the levels of IP-10,Rantes,hs-CRP and IL-6 were lower than those in the control group(P<0.05).Blood gas and lung function:The ar-terial blood oxygen partial pressure(PaO_(2))and FEV1%predicted value of the two groups increased(P<0.05)and arterial blood carbon dioxide partial pressure(PaCO_(2))decreased(P<0.05).The blood gas index and FEV1%predic

关 键 词：补肾宣肺方 慢性支气管炎 急性发作 炎症因子 

分 类 号：R256.1[医药卫生—中医内科学]