小檗碱联合来曲唑对超重/肥胖型多囊卵巢综合征患者卵巢形态及血流动力学的影响  

Effects of berberine combined with letrozole on ovarian morphology and he⁃modynamics in overweight/obese patients with polycystic ovary syndrome

作　　者：喻盈 周智 刘宝玲 兰芳 桑敏 YU Ying;ZHOU Zhi;LIU Bao-ing;LAN Fang;SANG Min(Reproductive Medicine Center,Huanggang Central Hospital of Yangtze University,Huanggang 438000,China)

机构地区：[1]长江大学附属黄冈市中心医院生殖医学中心,湖北黄冈438000

出　　处：《哈尔滨医科大学学报》2024年第1期85-88,99,共5页Journal of Harbin Medical University

基　　金：2024年度黄冈市科技创新专项一般项目(YBXM20240001)。

摘　　要：目的 探讨小檗碱联合来曲唑对超重/肥胖型多囊卵巢综合征(polycystic ovary syndrome, PCOS)患者卵巢形态及血流动力学的影响。方法 选取2022年1~11月在我院就诊的50例超重/肥胖型PCOS患者,将其随机分为对照组和观察组,每组各25例。对照组患者应用来曲唑诱导排卵治疗,观察组在此基础上联合应用小檗碱治疗,2组患者均连续治疗3个月经周期。对2组PCOS患者治疗前后卵巢形态及血流动力学指标进行比较。治疗后随访3个月,并记录2组患者排卵及月经情况。结果 与治疗前比较,2组患者在治疗后卵巢体积减小,卵泡直径增大,但观察组与对照组间无显著差异(P>0.05);2组患者卵泡数量降低,且观察组明显低于对照组(P<0.001)。与治疗前比较,2组患者治疗后卵巢动脉平均血流速度均增加,且观察组高于对照组(P<0.001);2组患者治疗后卵巢动脉搏动指数、阻力指数均降低,且观察组均低于对照组(P<0.001)。随访期间,2组患者治疗后排卵率及规律月经率均有改善,但两组间无明显差异(P>0.05)。结论 小檗碱联合来曲唑促排卵治疗对超重/肥胖型PCOS患者的卵巢形态及血流动力学有一定改善作用,可规律月经并促进排卵。Objective To explore the impact of berberine combined with letrozole on ovarian morphology and hemodynamics in overweight/obese patients with polycystic ovary syndrome(PCOS).Methods Fifty overweight/obese PCOS patients who visited our hospital from January to November 2022 were randomly divided into control group and observation group,with 25 patients in each group.Control group was treated with letrozole to induce ovulation,while the observation group was treated with berberine in combination.Both groups of patients were treated continuously for three menstrual cycles.Ovarian morphology and hemodynamic indicators between two groups of PCOS patients before and after treatment were compared.Followed up for 3 months after treatment,and the ovulation and menstrual status of two groups of patients were recorded.Resultss Compared with before treatment,the ovarian volume and follicle diameter of the two groups of patients decreased and increased after treatment,however,there was no significant difference between the two groups(P>0.05);The number of follicles in two groups of patients decreased,and the observation group showed significantly lower values compared with the control group(P<0.001).Compared with before treatment,the average blood flow velocity of ovarian arteries in both groups of patients increased after treatment,and the observation group was higher than the control group(P<0.001);After treatment,the ovarian artery pulsatility index and resistance index of both groups of patients decreased,and the values in the observation group were lower than those in the control group(P<0.001).During the followup period,the ovulation rate and regular menstrual cycle rate of both groups of patients were improved after treatment,but there was no significant difference between the two groups(P>0.05).Conclusion Berberine combined with letrozole has a certain improvement effect on ovarian morphology and hemodynamics in overweight/obese PCOS patients,which can regulate menstruation and promote ovulation.

关 键 词：多囊卵巢综合征 来曲唑 小檗碱 卵巢血流动力学 

分 类 号：R711.75[医药卫生—妇产科学]