单耐利福平与耐多药结核病患者178例临床特征  

Clinical characteristics of 178 cases of rifampicin mono-resistant or multidrug resistant tuberculosis

作　　者：陈金涛[1] 庄严[2] 杨改平[1] 孟丹 CHEN Jintao;ZHUANG Yan;YANG Gaiping;MENG Dan(Anyang Tuberculosis Control and Prevention Institute,Anyang,Henan 455000,China;Henan Center for Disease Control andPrevention)

机构地区：[1]安阳市结核病防治所,河南安阳455000 [2]河南省疾病预防控制中心

出　　处：《现代疾病预防控制》2024年第5期364-366,393,共4页MODERN DISEASE CONTROL AND PREVENTION

摘　　要：目的分析单耐利福平肺结核患者与耐多药肺结核患者临床特征,为制定耐药结核病的防控措施及治疗方案提供依据。方法收集2018—2022年就诊于河南省安阳市结核病防治所病原学阳性的肺结核病患者,比较单耐利福平与耐多药肺结核患者基本信息、实验室和影像学检查指标。结果单耐利福平与耐多药结核病患者178例,总耐药率10.21%,其中,单耐利福平64例,耐药率3.67%,耐多药114例,耐药率6.54%。2018—2022年单耐利福平和耐多药患者总耐药率呈下降趋势(χ^(2)_(趋势)=6.220,P<0.05)。既往是否中断治疗间比较,耐多药组治疗中断率65.79%高于单耐利福平组43.75%(χ^(2)=8.166,P<0.05);白细胞计数比较,耐多药组(9.39±2.88)×10^(9)/L高于单耐利福平组(8.03±2.62)×10^(9)/L(t=2.198,P<0.05);胸部CT评分比较,耐多药组(13.50±2.13)高于单耐利福平组(11.83±3.24)(t=0.560,P<0.05)。结论安阳市耐药肺结核总体呈现下降趋势,耐多药肺结核患者胸部影像学表现更严重,应加强耐药结核病患者的规范管理和治疗。Objective To analyze the clinical characteristics of rifampicin resistant pulmonary tuberculosis patients and multidrug resistant pulmonary tuberculosis patients so as to provide the evidence for formulating the prevention and control measures and treatment plans for drug-resistant tuberculosis.Methods The data of pathogenic positive pulmonary tuberculosis patients having doctor visit in Anyang Tuberculosis Control and Prevention Institute from 2018 to 2022 were collected,and the basic information,laboratory and imaging indicators between single drug resistant and multidrug resistant pulmonary tuberculosis patients were compared.Results There were 178 cases of rifampicin mono-resistant and multi drug resistant tuberculosis patients,with the total drug resistance rate of 10.21%;64 cases were rifampicin mono-resistant,with the drug resistance rate of 3.67%,and 114 cases were multi drug resistant,with the drug resistance rate of 6.54%.From 2018 to 2022,the overall resistance rate of patients with rifampicin mono-resistance and multidrug resistance showed a decreasing trend(χ^(2)_(trend)=6.220,P<0.05).About the comparison of whether treatment had been interrupted in the past,the interruption rate of treatment in the multidrug-resistant group was 65.79%,higher than that in the rifampicin mono-resistant group,which was 43.75%(χ^(2)=8.166,P<0.05);the comparison of white blood cell counts showed that in the multidrug-resistant group it was (9.39±2.88)×10^(9)/L,higher than that in the rifampicin mono-resistant group (8.03±2.62)×10^(9)/L (t=2.198,P<0.05);the comparison of chest CT scores showed that in the multidrug-resistant group it was (13.50±2.13),higher than that in the rifampicin mono-resistant group(11.83±3.24)(t=0.560,P<0.05).Conclusions The overall trend of drug resistant pulmonary tuberculosis in Anyang city shows a downward trend,and the chest imaging manifestation of multidrug resistant pulmonary tuberculosis patients is relatively serious.The standardized management and treatment of drug resistant tube

关 键 词：单耐利福平 耐多药肺结核 临床特征 

分 类 号：R521[医药卫生—内科学]