自体表皮移植序贯火针疗法治疗稳定期白癜风的临床研究  

Clinical observation of epidermal autograft followed by fire needling therapy in the treatment of stable vitiligo

作　　者：曹露 涂海燕 张宁宁 吴凯玲 曹珊珊 贺晓 赵阳 CAO Lu;TU Haiyan;ZHANG Ningning;WU Kaiing;CAO Shanshan;HE Xiao;ZHAO Yang(Department of Dermatology,General Hospital of Southern Theatre Command of PLA,Guangzhou,Guangdong 510010,China)

机构地区：[1]中国人民解放军南部战区总医院皮肤科,广东广州510010

出　　处：《安徽医药》2024年第7期1409-1412,I0004,共5页Anhui Medical and Pharmaceutical Journal

基　　金：中国人民解放军南部战区总医院育才基金课题项目(2022NZC014)。

摘　　要：目的探究自体表皮移植序贯火针疗法治疗稳定期白癜风的临床疗效。方法2019年6月至2020年6月在中国人民解放军南部战区总医院接受治疗的稳定期白癜风病人60例,采用随机数字表法分为单纯手术组与序贯治疗组,手术组单纯接受自体表皮移植术;序贯治疗组则在接受自体表皮移植术后2周,开始使用火针治疗植皮区。治疗14周后比较两组病人的临床转归和白癜风面积的复色率,观察不良反应的发生情况。结果治疗结束后评价两组临床疗效,序贯治疗组总有效率为100%,显效率为83.3%,明显高于单纯手术组(有效率80.0%,显效率53.3%),两组差异有统计学意义(P<0.05)。序贯治疗组复色率为(86.9±6.2)%,显著高于单纯手术组(65.5±3.6)%(P<0.05)。序贯治疗组病人在火针治疗过程中存在皮肤烧灼、疼痛等不适,两组病人均未观察到取皮区与植皮区伤口感染等不良反应。结论自体表皮移植术后序贯火针疗法对稳定期白癜风具有良好的疗效及安全性,值得临床推广。Objective To explore the clinical efficacy of autologous epidermal transplantation followed by fire acupuncture in the treatment of stable vitiligo.Methods Sixty patients with stable vitiligo were treated in the General Hospital of Southern Theatre Com-mand of PLA from June 2019 to June 2020.They were assigned into operation group and sequential treatment group by random number table method.The simple operation group only received autologous epidermal transplantation,while the sequential treatment group started to use fire acupuncture to treat the skin graft area 2 weeks after autologous epidermal transplantation.After 14 weeks of treat-ment,the clinical outcome and the repigmentation rate of the vitiligo area were compared between the two groups,and the adverse reac-tions during the treatment were recorded.Results The total effective rate in the sequential treatment group was 100%,and the marked-ly effective rate was 83.3%,which was significantly higher than that in the simple operation group(80.0%effective rate,53.3%marked-ly effective rate),and there was a significant difference between the two groups(P<0.05).The recoloration rate in the sequential treat-ment group was(86.9±6.2)%,which was significantly higher than that in the simple operation group(65.5±3.6)%,with a statistical dif-ference(P<0.05).The patients in the sequential treatment group had discomforts such as skin burning and pain,and they all significant-ly recovered after the treatment.No infection was observed in the skin harvesting area and skin grafting area in both groups.Conclu-sion Sequential fire acupuncture treatment after autologous epidermal transplantation has a good clinical effect and safety on stable vitiligo,which is worthy of clinical promotion.

关 键 词：白癜风 自体表皮移植 火针 临床转归 复色率 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]