艾司西酞普兰与氟西汀治疗对心血管疾病伴焦虑抑郁患者的影响分析  

Effect of Escitalopram and Fluoxetine Therapy on Patients with Cardiovascular Disease and Anxiety and Depression

作　　者：罗燕兰 张林潮 LUO Yanan;ZHANG Linchao(Department of Clinical Psychology,Liuzhou Liutie Central Hospital,Liuzhou,Guangxi Zhuang Autonomous Region,545000 China;Department of General Medicine,Liuzhou Liutie Central Hospital,Liuzhou,Guangxi Zhuang Autonomous Region,545000 China)

机构地区：[1]柳州市柳铁中心医院临床心理科,广西柳州545000 [2]柳州市柳铁中心医院全科医学科,广西柳州545000

出　　处：《中外医疗》2024年第12期9-12,共4页China & Foreign Medical Treatment

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z20200440)。

摘　　要：目的分析艾司西酞普兰与氟西汀治疗对心血管疾病伴焦虑抑郁患者心理状态的影响研究。方法单纯随机选取2020年3月—2022年2月柳州市柳铁中心医院100例心血管疾病伴焦虑抑郁患者作为研究对象,使用随机数表法进行分组,分为对照组(50例)和观察组(50例),两组患者均接受临床相同心血管药物治疗,对照组患者在心血管治疗的基础上采用氟西汀治疗,观察组患者在心血管治疗的基础上使用艾司西酞普兰治疗,对比两组相关的临床指标、心理情绪评分和不良反应。结果干预后,观察组患者广泛性焦虑障碍量表(Generalized Anxiety Disorder,GAD-7)评分(10.15±0.15)分、抑郁症状群量表(Patient Health Questionnaire-9,PHQ-9)评分(10.10±0.12)分低于对照组的(12.52±0.32)分、(12.29±0.27)分,差异有统计学意义(t=47.419、52.411,P均<0.05)。在干预前,所有患者的简易精神状态评价量表(Mini-mental State Examination,MMSE)、匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)比较,差异无统计学意义(P>0.05);干预后,观察组患者的各个数据优于对照组,差异有统计学意义(P均<0.05)。观察组患者的不良反应率低于对照组,差异有统计学意义(P<0.05)。结论综合医院心血管内科疾病合并焦虑抑郁状态的患者中,采取艾司西酞普兰治疗,能够帮助患者减轻焦虑、抑郁情绪,可以实现患者的身心状态改善,且不良反应较少。Objective To analyze the effect of escitalopram and fluoxetine treatment on the psychological state of patients with cardiovascular diseases accompanied by anxiety and depression.Methods Simple randomly selected from March 2020 to February 2022,Liuzhou,Liu tie Central Hospital,100 cases of cardiovascular disease with anxiety and depression patients as a research object,using the random number table method for grouping,divided into the control group(50 cases)and the observation group(50 cases),the two groups of patients received the same cardiovascular medication,the control group of patients in the cardiovascular treatment on the basis of the use of The patients in the control group were treated with fluoxetine on the basis of cardiovascular treatment,and the patients in the observation group were treated with escitalopram on the basis of cardiovascular treatment,comparing the clinical indicators,psychoemotional scores and adverse reactions of the two groups.Results After the intervention,patients in the observation group had a lower Generalized Anxiety Disorder(GAD-7)score(10.15±0.15)points and a lower Patient Health Questionnaire-9(PHQ-9)score(10.10±0.12)points than those in the control group(12.52±0.32)points and(12.29±0.27)points,the differences were statistically significant(t=47.419,52.411,both P<0.05).Before the intervention,all patients'scores on the Mini-mental State Examination(MMSE),Pittsburgh Sleep Quality Index(PSQI)were compared,the difference was not statistically significant(P<0.05);after the intervention,each data of the patients in the observation group was better than that of the control group,and the differences were statistically significant(all P<0.05).The rate of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In patients with cardiovascular diseases combined with anxiety and depression in general hospitals,escitalopram treatment can help patients reduce anxiety and depression,improve

关 键 词：心血管内科 焦虑 抑郁 

分 类 号：R541[医药卫生—心血管疾病]