奥美拉唑与泮托拉唑治疗消化道溃疡出血的效果研究  

Study on the Effect of Omeprazole and Pantoprazole in the Treatment of Peptic Ulcer Bleeding

作　　者：杨承彪 黎利平 YANG Chengbiao;LI Liping(Department of Gastroenterology,Leishan County People's Hospital,Leishan,Guizhou Province,557199 China)

机构地区：[1]雷山县人民医院消化内科,贵州雷山557199

出　　处：《中外医疗》2024年第12期109-112,共4页China & Foreign Medical Treatment

摘　　要：目的探讨奥美拉唑与泮托拉唑治疗消化道溃疡出血(Peptic Ulcer Bleeding,PUB)的临床价值。方法随机选取2021年10月—2023年10月雷山县人民医院收治的90例PUB患者作为研究对象,采用随机数表法分为两组,各45例。对照组行奥美拉唑治疗,观察组行泮托拉唑治疗。比较两组临床疗效、止血情况与恢复速度、空腹胃液pH值、幽门螺杆菌(Helicobacter Pylori,Hp)根治率、不良反应发生情况。结果观察组治疗总有效率为97.78%,高于对照组的84.44%,差异有统计学意义(χ^(2)=4.939,P=0.026)。观察组止血前出血量、止血前出血次数均优于对照组,止血用时、住院时间均短于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组的空腹胃液pH值、Hp根治率均高于对照组,不良反应总发生率低于对照组,差异有统计学意义(P均<0.05)。结论泮托拉唑治疗PUB的效果优于奥美拉唑,能够缩短止血时间与住院时间,减少出血次数及出血量,且在调节胃液pH值以及用药安全性等方面也有优势。Objective To investigate the clinical value of omeprazole and pantoprazole in the treatment of peptic ulcer bleeding(PUB).Methods A total of 90 PUB patients admitted to Leishan County People's Hospital from October 2021 to October 2023 were randomly selected as the study objects and divided into two groups with 45 cases each by random number table method.The control group was treated with omeprazole and the observation group was treated with pantoprazole.The clinical efficacy,hemostasis and recovery speed,pH value of fasting gastric fluid,radical treatment rate of helicobacter pylori(Hp)and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.78%,higher than that of the control group(84.44%),and the difference was statistically significant(χ^(2)=4.939,P=0.026).The amount of bleeding before hemostasis and the number of bleeding before hemostasis in the observation group were better than those in the control group,and the duration of hemostasis and hospital stay were shorter than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the fasting gastric juice pH value and the radical Hp treatment rate of the observation group were higher than those of the control group,and the total incidence of adverse reactions was lower than that of the control group,and the differences were statistically significant(all P<0.05).Conclusion The effect of pantoprazole in the treatment of PUB is better than omeprazole,which can shorten the time of hemostasis and hospitalization,reduce the number and amount of bleeding,and has advantages in regulating the pH value of gastric juice and drug safety.

关 键 词：消化道溃疡 溃疡出血 泮托拉唑 奥美拉唑 止血 免疫功能 

分 类 号：R969[医药卫生—药理学]