阻塞性睡眠呼吸暂停低通气综合征患者焦虑抑郁情绪与细胞因子的关系  

Association Between Anxious and Depressed Mood and Cytokines in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：赵顺鑫 杨磊[2] 王红民[1] ZHAO Shunxin;YANG Lei;WANG Hongmin(Department of Respiratory Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Psychiatry,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院呼吸内科,河南郑州450000 [2]郑州大学第一附属医院精神医学科,河南郑州450000

出　　处：《河南医学研究》2024年第11期1970-1974,共5页Henan Medical Research

摘　　要：目的 分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)伴焦虑抑郁患者多导睡眠监测(PSG)指标和细胞因子水平,探讨OSAHS伴发焦虑抑郁的发病机制。方法 回顾性纳入2020年2月至2022年12月郑州大学第一附属医院就诊的82例OSAHS伴焦虑抑郁患者(DA组)和75例单纯OSAHS患者(S组),对患者多导睡眠监测(PSG)、汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评分及细胞因子进行分析。结果 DA组呼吸暂停低通气指数(AHI)、呼吸暂停平均时间(A_(mean))、IL-18、IL-6和TNF-α水平高于S组,平均血氧饱和度(SaO_(2 mean))和INF-γ水平低于S组,差异有统计学意义(P<0.05)。DA组HAMD评分与IL-18、TNF-α水平和AHI呈正相关(r=0.296、0.250、0.238,P<0.05),HAMA评分与IL-6水平呈正相关(r=0.295,P<0.05),AHI与IL-18水平呈正相关(r=0.357,P<0.05)。结论 OSAHS伴焦虑抑郁患者症状更重、细胞因子水平存在着异常。细胞因子介导的免疫途径可能与OSASH患者伴发焦虑抑郁有关。Objective To analyze polysomnography(PSG)markers and cytokine levels in obstructive sleep apnea hypopnea syndrome(OSAHS)patients with anxiety and depression,and investigate the pathogenesis of OSAHS associated with anxiety and depression.Methods A total of 82 OSAHS patients with anxiety and depression(group DA)and 75 patients with simple OSAHS(group S)were collected from February 2020 to December 2022 in the First Affiliated Hospital of Zhengzhou University.PSG,Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA)scores and cytokines were analyzed.Results The apnea hypopnea index(AHI),mean apnea time(A mean),IL-18,IL-6 and TNF-αlevels in group DA were higher than those in group S,and the mean blood oxygen saturation(SaO_(2) mean)and INF-γlevels were lower than those in group S,and the differences were statistically significant(P<0.05).In group DA,HAMD score was positively correlated with IL-18,TNF-αlevels and AHI(r=0.296,0.250,0.238,P<0.05),HAMA score was positively correlated with IL-6 level(r=0.295,P<0.05),and AHI was positively correlated with IL-18 level(r=0.357,P<0.05).Conclusion OSAHS patients with anxiety and depression have more severe symptoms and abnormal cytokine levels.Cytokine-mediated immune pathway may be related to anxiety and depression in OSASH patients.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 细胞因子 焦虑 抑郁 

分 类 号：R563[医药卫生—呼吸系统]