围生期颅内血管超声预测身材矮小症的价值评估  

Evaluation of value of perinatal intracranial vascular ultrasound on predicting short stature

作　　者：康艳亭 何敏 刘丽 唐小燕 KANG Yanting;HE Min;LIU Li;TANG Xiaoyan(Department of Ultrasound,Yichun People's Hospital,Jiangxi Province,Yichun336000,China;Department of Ultrasound,Jiangxi Maternal and Child Health Hospital,Jiangxi Province,Nanchang330000,China)

机构地区：[1]江西省宜春市人民医院超声科,江西宜春336000 [2]江西省妇幼保健院超声科,江西南昌330000

出　　处：《中国当代医药》2024年第17期91-94,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202312203)。

摘　　要：目的评估围生期颅内血管超声预测身材矮小症的价值。方法采用回顾性分析,收集2020年1月至2023年6月在宜春市人民医院及江西省妇幼保健院医院正常产检、围生期(孕晚期、新生儿期)行颅内血管超声检查且出生后2~6年经生长激素激发试验被证实为身材矮小症的患儿50例作为观察组,同时收集出生身高正常且围生期已行颅内血管超声检查的50例儿童作为对照组,回顾两组在胎儿期以及新生儿期大脑中动脉的血流参数,包括收缩期最大血流速度(PSV)、舒张期最大血流速度(EDV),收缩期峰值血流速度与舒张末期血流速度的比值(S/D)、阻力指数(RI),分析上述参数预测身材矮小症的价值。结果孕晚期,两组胎儿大脑中动脉PSV、EDV、RI、S/D比较,差异无统计学意义(P>0.05)。新生儿期,观察组胎儿大脑中动脉PSV、EDV均低于对照组胎儿,差异有统计学意义(P<0.05)。新生儿期,观察组胎儿大脑中动脉RI高于对照组胎儿,差异有统计学意义(P<0.05)。新生儿期的大脑中动脉血流参数预测身材矮小症的效能较好,其中新生儿期大脑中动脉RI的预测效能最高,当大脑中动脉RI的截断值为>0.71 ml/min时,其Youden指数为0.637,曲线下面积(AUC)为0.771,预测身材矮小症的敏感度为76.19%,特异度为87.50%。结论身材矮小症患儿新生儿期大脑中动脉血流参数呈异常现象,且其对身材矮小症的预测效能较好,可为后续诊治提供有效指导。Objective To evaluate the value of perinatal intracranial vascular ultrasound on predicting short stature.Methods A total of 50 children who performed normal prenatal examination and perinatal(late pregnancy,neonatal period)intracranial vascular ultrasound examination and were confirmed as short stature by growth hormone provocation test at 2~6 years after birth in Yichun People's Hospital and Jiangxi Maternal and Child Health Hospital from January 2020 to June 2023 were collected as observation group using retrospective analysis,and 50 children with normal birth height who underwent perinatal intracranial vascular ultrasound examination were collected as control group.The blood flow parameters of middle cerebral artery in the two groups were reviewed in fetal period and neonatal period,including peak systolic velocity(PSV),maximum end-diastolic velocity(EDV),ratio of peak systolic velocity to end-diastolic velocity(S/D)and resistance index(RI),and the value of the above parameters on predicting short stature was analyzed.Results There were no significant differences of the PSV,EDV,RI and S/D of fetal middle cerebral artery in late pregnancy between two groups(P>0.05).In neonatal period,the PSV and EDV of fetal middle cerebral artery in observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The RI of fetal middle cerebral artery was higher than that in control group,with a significant difference(P<0.05).The blood flow parameters of middle cerebral artery in neonatal period had good efficiency on predicting short stature.The prediction efficiency of middle cerebral artery RI in the neonatal period was the highest.When the cut-off value of middle cerebral artery RI was>0.71 ml/min,the Youden index,area under the curve(AUC),sensitivity and specificity were 0.637,0.771,76.19%,and 87.50%in predicting short stature.Conclusion The blood flow parameters of middle cerebral artery are abnormal in neonatal period of children with short stature,and the above pa

关 键 词：围生儿 颅内血管超声 身材矮小症 预测价值 

分 类 号：R725.8[医药卫生—儿科]