超声剪切波弹性成像联合血清脂联素、尿激酶型纤溶酶原激活物对甲状腺结节良恶性的鉴别价值  

Diagnostic Value of Ultrasonic Shear Wave Elastography Combined with Serum Adiponectin and Urokinase Plasminogen Activator in Benign and Malignant Thyroid Nodules

作　　者：周娜 王蓓 王彪 乔瑜婷 牟洋 翟虹 ZHOU Na;WANG Bei;WANG Biao;QIAO Yu-ting;MU Yang;ZHAI Hong(Department of Abdominal Ultrasound,Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital,Urumqi,Xinjiang,830000,China)

机构地区：[1]新疆维吾尔自治区中医医院腹部超声科,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2024年第8期1478-1481,1515,共5页Progress in Modern Biomedicine

基　　金：新疆维吾尔自治区自然科学基金项目(2018D01C292);新疆医科大学附属中医医院院级课题(ZYY201818)。

摘　　要：目的:探讨超声剪切波弹性成像(SWE)联合血清脂联素(AFN)、尿激酶型纤溶酶原激活物(uPA)鉴别甲状腺结节良恶性的价值。方法:选择2020年1月至2022年12月我院收治的行甲状腺外科切除手术治疗的127例甲状腺结节患者,所有患者术前接受SWE检查,检测血清AFN、uPA水平,记录术后病理结果,并根据术后病理结果将患者分为恶性组和良性组。分析SWE参数联合血清AFN、uPA鉴别甲状腺结节良恶性的价值。结果:经术后病理检查证实,恶性结节21例(恶性组),良性结节106例(良性组)。恶性组弹性模量最大值(Max)、弹性模量最小值(Min)、弹性模量平均值(Mean),血清uPA水平高于良性组(P<0.05),血清AFN水平低于良性组(P<0.05)。Max、Mean、Min、AFN、uPA鉴别甲状腺结节良恶性的曲线下面积分别为0.609、0.754、0.600、0.777、0.701,联合Max、Mean、Min、AFN、uPA鉴别甲状腺结节良恶性的曲线下面积为0.935,高于各指标单独鉴别。结论:恶性甲状腺结节患者SWE参数Max、Mean、Min和血清uPA水平增加,AFN水平降低,联合SWE参数和血清AFN、uPA可提高对甲状腺结节性质的鉴别效能。Objective:To investigate the value of ultrasonic shear wave elastography(SWE)combined with serum adiponectin(AFN)and urokinase plasminogen activator(uPA)in differentiating benign and malignant thyroid nodules.Methods:127 patients with thyroid nodules who underwent surgical thyroidectomy were selected in our hospital from January 2020 to December 2022.All patients underwent SWE examination before surgery,serum AFN and uPA levels were detected,and postoperative pathological results were recorded.According to the postoperative pathological results,the patients were divided into malignant group and benign group.Analyzed the value of SWE parameters combined with serum AFN and uPA in differentiating benign and malignant thyroid nodules.Results:There were 21 cases of malignant nodules(malignant group)and 106 cases of benign nodules(benign group).In the malignant group,the serum uPA level was higher than that in the benign group(P<0.05),and the serum AFN level was lower than that in the benign group(P<0.05).The area under the curve of Max,Mean,Min,AFN and uPA were 0.609,0.754,0.600,0.777 and 0.701,respectively,and the area under the curve of combined Max,Mean,Min,AFN and uPA was 0.935,higher than each indicator to identify separately.Conclusion:In patients with malignant thyroid nodules,SWE parameters Max,Mean,Min and serum uPA levels increased,while AFN levels decreased.Combining SWE parameters with serum AFN and uPA can improve the differential efficacy of thyroid nodules.

关 键 词：超声剪切波弹性成像 脂联素 尿激酶纤溶酶原激活物 甲状腺结节 鉴别价值 

分 类 号：R581[医药卫生—内分泌] R445[医药卫生—内科学]