散结镇痛胶囊联合孕三烯酮对子宫内膜异位症患者性激素、子宫动脉血流动力学和血清MMPs的影响  

Effect of Sanjie Analgesic Capsule Combined with Gestrinone on Sex Hormone,Uterine Artery Hemodynamics,and Serum MMPs in Patients with Endometriosis

作　　者：梁琳 陈滢 魏华芳 王媛媛 宋成文 LIANG Lin;CHEN Ying;WEI Hua-fang;WANG Yuan-yuan;SONG Cheng-wen(Department of Gynaecology and Obstetrics,Central Theater Command General Hospital of the Chinese People's Liberation Army,Wuhan,Hubei,430064,China;Department of Gynaecology,Central Theater Command General Hospital of the Chinese People's Liberation Army,Wuhan,Hubei,430064,China)

机构地区：[1]中国人民解放军中部战区总医院妇产科,湖北武汉430064 [2]中国人民解放军中部战区总医院妇科,湖北武汉430064

出　　处：《现代生物医学进展》2024年第8期1486-1489,共4页Progress in Modern Biomedicine

基　　金：湖北省卫健委青年人才项目(WJ2017H0035)。

摘　　要：目的:探讨孕三烯酮和散结镇痛胶囊联合治疗对子宫内膜异位症(EMT)患者性激素、子宫动脉血流动力学和血清基质金属蛋白酶(MMPs)的影响。方法:选取中国人民解放军中部战区总医院2021年1月~2022年12月期间收治的EMT患者195例,采用双色球法将患者分为对照组(孕三烯酮治疗,n=97)和观察组(散结镇痛胶囊联合孕三烯酮治疗,n=98)。对比两组疗效、性激素指标、子宫动脉血流动力学和血清MMP-2、MMP-3、MMP-9/基质金属蛋白酶抑制剂-1(TIMP-1)水平,同时观察两组不良反应发生率。结果:与对照组相比,观察组的临床总有效率更高(P<0.05)。治疗后,观察组卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))低于对照组(P<0.05)。治疗后,观察组搏动指数(PI)、阻力指数(RI)低于对照组,收缩期最大流速(PSV)、舒张末期流速(EDV)高于对照组(P<0.05)。治疗后,观察组MMP-2、MMP-3、MMP-9/TIMP-1低于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论:散结镇痛胶囊联合孕三烯酮可有效改善EMT患者性激素、子宫动脉血流动力学和血清MMP-2、MMP-3、MMP-9/TIMP-1水平,且安全性好。Objective:To investigate the effect of the combination therapy of gestrinone and Sanjie analgesic capsule on sex hormone,uterine artery hemodynamics,and serum matrix metalloproteinases(MMPs)in patients with endometriosis(EMT).Methods:195 patients with EMT admitted to the Central Theater Command General Hospital of the Chinese People's Liberation Army from January 2021 to December 2022 were selected,and patients were divided into the control group(gestrinone treatment,n=97)and the observation group(Sanjie analgesic capsule combined with gestrinone treatment,n=98)by the dual color sphere method.The efficacy,sex hormone indexes,uterine arterial hemodynamics and serum MMP-2,MMP-3 and MMP-9/tissue inhibitor of matrix metalloproteinase-1(TIMP-1)levels were compared between the two groups,and simultaneously observed the incidence of adverse reactions in both groups.Results:Compared with the control group,the clinical total effective rate of observation group was higher(P<0.05).After treatment,the follicle stimulating hormone(FSH),luteinizing hormone(LH),and estradiol(E_(2))of the observation group were lower than those of the control group(P<0.05).After treatment,the pulsatile index(PI)and resistance index(RI)of the observation group were lower than those of the control group,while the peak systolic velocity(PSV)and end-diastolic velocity(EDV)were higher than those of the control group(P<0.05).After treatment,the MMP-2,MMP-3,MMP-9/TIMP-1 of the observation group were lower than those of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Sanjie analgesic capsule combined with gestrinone could effectively improve sex hormones,uterine artery hemodynamics,and serum MMP-2,MMP-3,MMP-9/TIMP-1 levels in patients with EMT,and which had good safety.

关 键 词：散结镇痛胶囊 孕三烯酮 子宫内膜异位症 性激素 子宫动脉血流动力学 MMPS 

分 类 号：R711.71[医药卫生—妇产科学]