不同剂量蛋白质饮食对2型糖尿病合并肺结核患者营养状况、免疫功能及氧化应激水平的影响  

Effects of Different Doses of Protein Diet on Nutritional Status,Immune Function and Oxidative Stress in Patients with Type 2 Diabetes Mellitus with Pulmonary Tuberculosis

作　　者：刘春香 李芳 卓小华 黄凰 雷敏 LIU Chun-xiang;LI Fang;ZHUO Xiao-hua;HUANG Huang;LEI Min(Third Department of Internal Medicine,Hunan Provincial Chest Hospital,Changsha,Hunan,410006,China)

机构地区：[1]湖南省胸科医院内三科,湖南长沙410006

出　　处：《现代生物医学进展》2024年第8期1540-1544,共5页Progress in Modern Biomedicine

基　　金：湖南省卫生健康委科研计划课题项目(C20200639)。

摘　　要：目的:探讨不同剂量蛋白质饮食对2型糖尿病(T2DM)合并肺结核患者营养状况、免疫功能及氧化应激水平的影响。方法:选取湖南省胸科医院2020年3月~2021年12月期间收治的T2DM合并肺结核患者120例作为研究对象。采用随机数字法分为高蛋白组(1.5 g/kg/d蛋白、总热量上调10%)、中蛋白组(1.2 g/kg/d蛋白、总热量上调10%)、低蛋白组(1.0 g/kg/d蛋白、总热量上调10%),各为40例。对比三组患者的痰液结核分枝杆菌转阴情况、肺部感染情况、血糖情况、营养状况、免疫功能及氧化应激水平。结果:高蛋白组、中蛋白组的痰液结核分枝杆菌转阴率高于低蛋白组,且高蛋白组高于中蛋白组(P<0.05)。高蛋白组、中蛋白组的肺部感染率低于低蛋白组,且高蛋白组低于中蛋白组(P<0.05)。治疗后,高蛋白组、中蛋白组的糖化血红蛋白(Hb A1c)、空腹血糖(FBG)、餐后2 h血糖(2h PG)低于低蛋白组,且高蛋白组低于中蛋白组(P<0.05)。治疗后,高蛋白组、中蛋白组的总白蛋白(TP)、前白蛋白(PA)及白蛋白(ALB)高于低蛋白组,且高蛋白组高于中蛋白组(P<0.05)。治疗后,高蛋白组、中蛋白组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于低蛋白组,且高蛋白组高于中蛋白组(P<0.05)。治疗后,高蛋白组、中蛋白组的CD8^(+)低于低蛋白组,且高蛋白组低于中蛋白组(P<0.05)。治疗后,高蛋白组、中蛋白组的超氧化物歧化酶(SOD)高于低蛋白组,且高蛋白组高于中蛋白组(P<0.05)。治疗后,高蛋白组、中蛋白组的丙二醛(MDA)低于低蛋白组,且高蛋白组低于中蛋白组(P<0.05)。结论:高蛋白质饮食对T2DM合并肺结核患者营养状况、免疫功能的改善效果较好,同时还可降低氧化应激水平。Objective:To investigate the effects of different doses of protein diet on nutritional status,immune function and oxidative stress in patients with type 2 diabetes mellitus(T2DM)with pulmonary tuberculosis.Methods:120 T2DM patients with pulmonary tuberculosis who were admitted to Hunan Provincial Chest Hospital from March 2020 to December 2021 were selected as research objects.Patients were randomly divided into high protein group(1.5 g/kg/d protein,total calorie increased by 10%),medium protein group(1.2 g/kg/d protein,total calorie increased by 10%),low protein group(1.0 g/kg/d protein,total calorie increased by 10%).40 cases in each group.The sputum mycobacterium tuberculosis negative conversion,pulmonary infection,blood glucose,nutritional status,immune function and oxidative stress level in three groups were compared.Results:The sputum mycobacterium tuberculosis negative conversion rate in high protein group and medium protein group was higher than that in low protein group,and high protein group was higher than that of medium protein group(P<0.05).The pulmonary infection rate in high protein group and medium protein group was lower than that in low protein group,and high protein group was lower than that of medium protein group(P<0.05).After treatment,the glycosylated hemoglobin(HbA1c),fasting blood glucose(FBG)and 2h postprandial blood glucose(2hPG)in high protein group and medium protein group were lower than those in low protein group,and high protein group was lower than that of medium protein group(P<0.05).After treatment,total albumin(TP),prealbumin(PA)and albumin(ALB)in high protein group and medium protein group were higher than those in low protein group,and high protein group was higher than that of medium protein group(P<0.05).After treatment,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in high protein group and medium protein group were higher than those in low protein group,and high protein group was higher than that of medium protein group(P<0.05).After treatment,CD8^(+)in high protein group and medium p

关 键 词：不同剂量 蛋白质饮食 2型糖尿病 肺结核 营养状况 免疫功能 氧化应激 

分 类 号：R587.2[医药卫生—内分泌] R521[医药卫生—内科学]