时钟基因Rev-erbα在运动诱导线粒体生物合成中的作用及可能机制  

Role and Possible Mechanism of Clock Gene Rev-erbαin Exercise-induced Mitochondrial Biogenesis

作　　者：杨婷婷 程凤佳 高扬 于亮[1] YANG Ting-Ting;CHENG Feng-Jia;GAO Yang;YU Liang(School of Sport Human Science,Beijing Sport University,Beijing 100084,China)

机构地区：[1]北京体育大学运动人体科学学院,北京100084

出　　处：《生物化学与生物物理进展》2024年第6期1357-1370,共14页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(32071168);中央高校基本科研业务费专项基金(2022YB019,20221013,20221019)资助项目。

摘　　要：线粒体生物合成是细胞适应能量需求、维持能量稳态的重要手段,其过程受到生物钟系统的全局调控。作为机体的能量供应站点,线粒体生物合成障碍与各种疾病的发生发展密切相关。时钟基因Rev-erbα能整合昼夜节律与能量代谢,在调节线粒体生物合成过程中起到了重要作用。运动作为一种行之有效的改善健康、促进恢复的非药用方式,不仅能促进线粒体生物合成增强,还与Rev-erbα存在着双向调节,因此考虑Rev-erbα可能是运动诱导线粒体生物合成的中介物质。本文就Rev-erbα在调节线粒体生物合成中的作用、影响Rev-erbα的可能因素、运动与Rev-erbα的相互作用及运动通过Rev-erbα诱导线粒体生物合成的潜在机制进行了梳理和探讨,以期为运动促进线粒体生物合成机制提供理论参考。The clock gene Rev-erbα,also known as nuclear receptor subfamily 1 group D member 1(Nr1d1),is a crucial regulatory factor in organisms.It exhibits circadian rhythmic expression in metabolically active tissues such as skeletal muscles,heart,liver,and adipose tissue,responding to various environmental stimuli.Rev-erbαplays a significant role in regulating circadian rhythms,metabolic homeostasis,and other physiological processes,earning its designation as an“integrator”of the circadian system and metabolism.Rev-erbαestablishes complex connections with other clock genes through the transcriptional-translational feedback loop(TTFL),which is important for the rhythmic output of biological clock system and for the relative stability of phases and cycles.Mitochondrial biogenesis is a physiological process initiated by cells to maintain energy homeostasis by using existing mitochondria as a template for self-growth and division.As the“energy factory”of organism,disruptions in mitochondrial biogenesis are closely associated with the development of various diseases.Studies have shown that not only the factors involved in mitochondrial biogenesis have circadian oscillations,but also the morphology,dynamics and energy metabolism of mitochondria themselves have cyclic fluctuations throughout the day,suggesting that mitochondrial biogenesis is regulated by the biological clock system,in which the clock gene Rev-erbαplays a key role,it drives mitochondrial biogenesis and synergistically regulates autophagy to normalize a number of physiological processes in the body.Rev-erbαis sensitive to both internal and external environmental changes,and disruptions in circadian rhythms,metabolic diseases,and aging are significant inducers of changes in Rev-erbαexpression,and its concomitant inflammation and oxidative stress may be an intrinsic mechanism for inhibiting mitochondrial biogenesis.Therefore,the enhancement of mitochondrial biogenesis by regulating the Rev-erbαactivity status may be an important way to improve the

关 键 词：Rev-erbα 线粒体生物合成 运动 昼夜节律 

分 类 号：R87[医药卫生—运动医学] R337.1[医药卫生—临床医学]