白藜芦醇抗乳腺癌的研究进展  

Research on the role of resveratrol against breast cancer

作　　者：高庆东 段旭昉 李妍[3] 许涛 于洋洋 白国栋 GAO Qingdong;DUAN Xufang;LI Yan;XU Tao;YU Yangyang;BAI Guodong(Dept.of Pharmacy,Jiamusi Hospital of TCM,Heilongjiang Jiamusi 154002,China;Dept.of Pharmacy,Jiamusi Xiangyang District People’s Hospital,Heilongjiang Jiamusi 154002,China;Dept.of Pharmacy,the Fourth Affiliated Hospital of Heilongjiang University of TCM,Harbin 150006,China;Preparation Room,Jiamusi Hospital of TCM,Heilongjiang Jiamusi 154002,China)

机构地区：[1]佳木斯市中医医院药剂科,黑龙江佳木斯154002 [2]佳木斯市向阳区人民医院药剂科,黑龙江佳木斯154002 [3]黑龙江中医药大学附属第四医院药剂科,哈尔滨150006 [4]佳木斯市中医医院制剂室,黑龙江佳木斯154002

出　　处：《中国药房》2024年第11期1408-1412,共5页China Pharmacy

基　　金：黑龙江省重点研发计划重点领域专项(No.2022ZXJ03B18)。

摘　　要：乳腺癌的发病率在女性恶性肿瘤中高居榜首,具有侵袭性强、恶性程度高、预后差的特征。白藜芦醇是一种植物抗氧化剂,在对抗乳腺癌发生和发展中具有潜在的多效性。本文通过评估多个体外和体内研究以探索白藜芦醇干预乳腺癌的作用机制,发现白藜芦醇可通过诱导细胞凋亡,调控自噬,抑制糖酵解,调节肿瘤微环境、基质金属蛋白酶、上皮-间质转化、耐药蛋白等的表达,来削弱乳腺癌细胞的增殖和存活能力,抑制乳腺癌细胞的生长、转移和侵袭,逆转乳腺癌细胞对阿霉素的耐药。白藜芦醇的临床试验研究数量有限,主要是关于其对乳腺癌的预防作用,这可能是影响全面评估白藜芦醇抗癌效果的原因之一。Breast cancer(BC)ranks first in the incidence rate of female malignant tumor,the notable features of which include high invasive behavior,high malignant degree and poor prognosis.Resveratrol,a plant antioxidant,has been identified as a potential therapeutic agent for the occurrence and progress of BC.This article explores the mechanism of resveratrol intervention in BC by evaluating several in vitro and in vivo studies.It was found that resveratrol can weaken the proliferation and survival ability of BC cells,suppress their growth,metastasis,and invasion,and reverse their resistance to adriamycin by promoting cell apoptosis,regulating autophagy,inhibiting glycolysis and regulating the tumor microenvironment,expressions of matrix metalloproteinases,epithelial-mesenchymal transition and drug-resistant proteins,etc.The limited number of clinical trial studies on resveratrol,mainly focusing on prevention effect of it on breast cancer,may be one of the reasons that affect the comprehensive evaluation of the anti-cancer efficacy of resveratrol.

关 键 词：白藜芦醇 乳腺癌 细胞凋亡 自噬 糖酵解 肿瘤微环境 细胞侵袭 细胞转移 耐药 

分 类 号：R965[医药卫生—药理学]