血清COL10A1、TK1、MIP-3α水平与胃癌患者病理特征的关系及其对腹膜转移的诊断价值研究  

Relationship between serum COL10A1,TK1 and MIP-3αlevels with pathological features in patients with gastric cancer and their diagnostic value for peritoneal metastasis

作　　者：王佩显 单彪[1] 张倩倩 吴殿超[3] 雷秋香[2] WANG Peixian;SHAN Biao;ZHANG Qianqian;WU Dianchao;LEI Qiuxiang(Department of Blood Transfusion,Xingtai Municipal People′s Hospital,Xingtai,Hebei 054000,China;Department of Clinical Laboratory,Xingtai Municipal People′s Hospital,Xingtai,Hebei 054000,China;Department of Gastrointestinal Oncology,Xingtai Municipal People′s Hospital,Xingtai,Hebei 054000,China)

机构地区：[1]河北省邢台市人民医院输血科,河北邢台054000 [2]河北省邢台市人民医院检验科,河北邢台054000 [3]河北省邢台市人民医院胃肠肿瘤科,河北邢台054000

出　　处：《检验医学与临床》2024年第12期1727-1730,1738,共5页Laboratory Medicine and Clinic

基　　金：2023年度河北省医学科学研究课题计划项目(20232013)。

摘　　要：目的研究血清X型胶原α1链(COL10A1)、胸苷激酶1(TK1)、巨噬细胞炎症蛋白-3α(MIP-3α)水平与胃癌患者病理特征的关系及其对胃癌腹膜转移的诊断价值。方法以2021年1月至2022年12月邢台市人民医院收治的96例胃癌患者作为恶性组,其中有腹膜转移27例,无腹膜转移69例;选取同期收治的104例胃良性病变患者作为良性病变组,选取112例健康体检者作为健康对照组。比较各组血清COL10A1、TK1、MIP-3α水平及不同病理特征、有无腹膜转移胃癌患者血清COL10A1、TK1、MIP-3α水平,采用受试者工作特征(ROC)曲线分析血清COL10A1、TK1、MIP-3α对胃癌患者腹膜转移的诊断价值。结果恶性组血清COL10A1、MIP-3α、TK1水平高于健康对照组、良性病变组,良性病变组血清COL10A1、MIP-3α水平高于健康对照组,差异均有统计学意义(P<0.05)。低/未分化、有脉管浸润、肿瘤临床病理分期(TNM)分期Ⅲ~Ⅳ期胃癌患者血清COL10A1、TK1、MIP-3α水平高于高/中分化、无脉管浸润、TNM分期Ⅰ~Ⅱ期患者(P<0.05)。有腹膜转移胃癌患者血清COL10A1、TK1、MIP-3α水平高于无腹膜转移患者(P<0.05)。血清COL10A1、TK1、MIP-3α单项及3项联合检测诊断胃癌腹膜转移的曲线下面积(AUC)分别为0.722(95%CI:0.621~0.809)、0.749(95%CI:0.651~0.832)、0.736(95%CI:0.637~0.821)、0.853(95%CI:0.766~0.917),3项联合检测诊断的AUC大于3项单独检测(Z=1.990、3.617、2.986,P<0.001)。结论胃癌的发生导致患者血清COL10A1、TK1、MIP-3α水平升高,同时随着胃癌患者病情的进展,血清COL10A1、TK1、MIP-3α水平升高,且3项指标联合检测对胃癌患者腹膜转移具有较好的诊断价值。Objective To investigate the relationship between serum collagen Xα1 chain(COL10A1),thymidine kinase 1(TK1)and macrophage inflammatory protein-3α(MIP-3α)levels with pathological characteristics in the patients with gastric cancer and their diagnostic value for peritoneal metastasis.Methods A total of 96 patients with gastric cancer admitted and treated in Xingtai Municipal People′s Hospital from January 2021 to December 2022 were selected as the malignant group,including 27 cases of peritoneal metastasis and 69 cases of non-peritoneal metastasis;104 patients with benign gastric lesions admitted and treated during the same period served as the benign lesion group,and 112 healthy subjects undergoing physical examination were selected as the healthy control group.The serum COL10A1,TK1 and MIP-3αlevels were compared among different groups,and serum COL10A1,TK1 and MIP-3αlevels were compared among the gastric cancer patients with different pathological features and with or without peritoneal metastasis.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum COL10A1,TK1 and MIP-3αfor peritoneal metastasis in the patients with gastric cancer.Results The serum COL10A1,TK1 and MIP-3αlevels in the malignant group were higher than those in the healthy control group and benign lesion group.The serum COL10A1 and MIP-3αlevels in the benign lesion group were higher than those in the healthy control group,and the differences were statistically significant(P<0.05).The serum COL10A1,TK1 and MIP-3αlevels in the patients with low/undifferentiated,vascular infiltration,and tumor clinical pathological staging(TNM)stageⅢ-Ⅳgastric cancer were higher than those in the patients with high/medium differentiation,no vascular infiltration and TNM stagesⅠ-Ⅱ(P<0.05).Serum COL10A1,TK1 and MIP-3αlevels in gastric cancer patients with peritoneal metastasis were higher than those in the patients without peritoneal metastasis(P<0.05).The areas under the curve(AUC)of serum COL10A1,TK1 and

关 键 词：胃癌 X型胶原α1链 胸苷激酶1 巨噬细胞炎症蛋白-3α 病理特征 腹膜转移 诊断 

分 类 号：R446.11[医药卫生—诊断学] R735.2[医药卫生—临床医学]