HGI、u-ALB及TNC与2型糖尿病视网膜病变的相关性研究  

Relationship between HGI,u-ALB and TNC and type 2 diabetic retinopathy

作　　者：董晓芬 李香波 吴震宇 DONG Xiao-fen;LI Xiang-bo;WU Zhen-yu(Department of Endocrinology,Daxing Teaching Hospital,Capital Medical University,Beijing 102600,China)

机构地区：[1]首都医科大学大兴教学医院内分泌科,北京102600

出　　处：《临床和实验医学杂志》2024年第10期1044-1048,共5页Journal of Clinical and Experimental Medicine

基　　金：北京市自然科学基金(编号:2021087B);北京市大兴区人民医院科研课题(编号:4202321477)。

摘　　要：目的研究糖化血红蛋白变异指数(HGI)、尿微量白蛋白(u-ALB)及血清腱生蛋白C(TNC)与2型糖尿病视网膜病变(T2DR)的相关性。方法回顾性选择2021年4月至2023年5月于首都医科大学大兴教学医院接受治疗的2型糖尿病(T2DM)患者1390例的临床资料,根据T2DR发生情况将其分为T2DR组(n=378)和非T2DR组(n=1012)。依据糖尿病视网膜病变早期治疗研究分类系统对T2DR患者进行分期,分为非增殖期T2DR组(n=275)和增殖期T2DR(n=103)。观察两组基线资料(性别、年龄、T2DM病程)、血糖[空腹血糖(FBG)、餐后2 h血糖(2 h PBG)]、血脂[高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇、甘油三酯]、HGI、u-ALB及血清TNC水平;观察不同T2DR病变分期患者基线资料、血糖、血脂、HGI、u-ALB、血清TNC水平。采用Pearson相关分析对T2DM患者HGI、u-ALB、血清TNC与T2DR的相关性进行分析。采用多因素Logistic回归分析对影响T2DR发生的独立危险因素进行分析。结果T2DR组与非T2DR组的性别构成比、年龄比较,差异均无统计学意义(P>0.05);T2DR组T2DM病程、FPG、2 h PBG、HbA1c、HDL-C、LDL-C、总胆固醇、甘油三酯、HGI、u-ALB、TNC水平均大于非T2DR组,差异均有统计学意义(P<0.05)。增殖期T2DR组与非增殖期T2DR组的性别构成比、年龄比较,差异均无统计学意义(P>0.05);增殖期T2DR组的T2DM病程、FPG、2 h PBG、HbA1c、HDL-C、LDL-C、总胆固醇、甘油三酯、HGI、u-ALB、TNC水平均大于非增殖期T2DR组,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,HGI、u-ALB、TNC与T2DM患者发生T2DR呈正相关(P<0.05)。多因素Logistic回归分析结果显示,HbA1c、HGI、u-ALB及TNC为影响T2DM患者发生T2DR的独立危险因素。结论HGI、u-ALB、TNC的异常升高可促进T2DM患者T2DR的发生及进展,HbA1c、HGI、u-ALB及TNC为影响T2DM患者发生T2DR的独立危险因素。Objective To study the correlation of hemoglobin glycation index(HGI),urinary microalbumin(u-ALB)and serum tendinogenic protein C(TNC)with type 2 diabetic retinopathy(T2DR).Methods The clinical data of 1390 type 2 diabetes mellitus(T2DM)patients treated in Daxing Teaching Hospital,Capital Medical University from April 2021 to May 2023 were retrospectively selected.According to the occurrence of T2DR they were into the T2DR group(n=378)and the non-T2DR group(n=1012).According to the research classification system for early treatment of diabetes retinopathy,T2DR patients were divided into the non proliferative T2DR group(n=275)and the proliferative T2DR group(n=103).The baseline data(gender,age,duration of T2DM),the blood glucose[fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PBG)],blood lipids[high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),total cholesterol,triglycerides],HGI,u-ALB and serum TNC levels of patients in the T2DR group and the non-T2DR group were observed.The baseline data,blood glucose,blood lipids,HGI,u-ALB and serum TNC levels of patients with different stages of T2DR were observed.The correlation between HGI,u-ALB,serum TNC and T2DR in T2DM patients was analyzed by Pearson correlation.Multivariate Logistic regression was used to analyze the independent risk factors for T2DR in T2DM patients.Results There were no statistically significant differencee in gender composition ratio and age between the T2DR group and the non T2DR group(P>0.05);the course of T2DM,FPG,2 h PBG,HbA1c,HDL-C,LDL-C,total cholesterol,triglycerides,HGI,u-ALB,and TNC levels in the T2DR group were all higher than those in the non T2DR group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in gender composition ratio and age between the proliferative and T2DR group non proliferative T2DR group(P>0.05);the course of T2DM,FPG,2 h PBG,HbA1c,HDL-C,LDL-C,total cholesterol,triglycerides,HGI,u-ALB,and TNC levels in the prol

关 键 词：2型糖尿病 糖尿病视网膜病变 糖化血红蛋白变异指数 尿微量白蛋白 腱生蛋白C 相关性 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]