基于两样本孟德尔随机化探讨BMI增高与慢性皮肤溃疡的关系  

Causal relationship between BMI and chronic skin ulcer based on two sample mendelian randomization

作　　者：邢基祥 齐璐瑶 孙旭 张朝晖[3] XING Jixiang;QI Luyao;SUN Xu;ZHANG Zhaohui(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;不详)

机构地区：[1]天津中医药大学研究生院,301617 [2]上海中医药大学附属第七人民医院重症医学科 [3]天津中医药大学第二附属医院中医外科

出　　处：《浙江医学》2024年第11期1173-1176,I0007,共5页Zhejiang Medical Journal

基　　金：天津中医药大学第二附属医院育才计划科技项目(YC-FY202302)。

摘　　要：目的基于两样本孟德尔随机化(TSMR)探讨BMI增高与慢性皮肤溃疡(CSU)的关系。方法通过全基因组关联研究数据库筛选出与BMI强相关的工具变量,在FinnGen数据库筛选CSU数据。采用TSMR分析BMI增高与CSU的关系;采用MR-Egger与逆方差加权法(IVW)检验数据异质性,MR-Egger检验数据水平多效性。结果共有334个单核苷酸多态性进行TSMR分析:其中IVW、Weighted median显示BMI增高会增加CSU的发生风险(OR=1.638、1.860,均P<0.01);而MR-Egger、Simple mode、Weighted mode等3种检验方法结果均不显著(均P>0.05)。所有数据均不存在异质性和水平多效性(均P>0.05),提示数据稳健性强且可靠。结论基于TSMR分析提示BMI增高会增加CSU的发生风险。Objective To explore the causal relationship between BMI and chronic skin ulcer(CSU)based on two sample mendelian randomization(TSMR).Methods Instrumental variables strongly associated with BMI were screened out through the genome-wide association study,and CSU data were selected from the FinnGen database.The causal relationship between BMI and CSU was analyzed using TSMR.The MR-Egger and inverse variance weighted(IVW)were used to test the heterogeneity,and the MR-Egger was used to test the horizontal pleiotropy.Results A total of 334 single nucleotide polymorphisms were analyzed by TSMR.IVW and Weighted median showed that BMI increased the risk of CSU(OR=1.638,1.860,both P<0.01).However,the results of MR-Egger,Simple mode,and Weighted mode were not significant(all P>0.05).There was no heterogeneity or horizontal pleiotropy in all the data(all P>0.05),suggesting that the data were robust and reliable.Conclusion TSMR analysis indicates that elevated BMI may increase the risk of CSU.

关 键 词：孟德尔随机化 慢性皮肤溃疡 体重指数 因果关系 

分 类 号：R632.1[医药卫生—外科学]